TY - JOUR
T1 - Exercise is medicine? The cardiorespiratory implications of ultra-marathon
AU - Tiller, Nicholas B.
AU - Stewart, Glenn M.
AU - Illidi, Camilla R.
AU - Levine, Benjamin D.
N1 - Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2020
Y1 - 2020
N2 - Regular physical activity decreases the risk of cardiovascular disease, type II diabetes, obesity, certain cancers, and all-cause mortality. Nevertheless, there is mounting evidence that extreme exercise behaviors may be detrimental to human health. This review collates several decades of literature on the physiology and pathophysiology of ultra-marathon running, with emphasis on the cardiorespiratory implications. Herein, we discuss the prevalence and clinical significance of postrace decreases in lung function and diffusing capacity, respiratory muscle fatigue, pulmonary edema, biomarkers of cardiac injury, left/right ventricular dysfunction, and chronic myocardial remodeling. The aim of this article is to inform risk stratification for ultra-marathon and to edify best practice for personnel overseeing the events (i.e., race directors and medics).
AB - Regular physical activity decreases the risk of cardiovascular disease, type II diabetes, obesity, certain cancers, and all-cause mortality. Nevertheless, there is mounting evidence that extreme exercise behaviors may be detrimental to human health. This review collates several decades of literature on the physiology and pathophysiology of ultra-marathon running, with emphasis on the cardiorespiratory implications. Herein, we discuss the prevalence and clinical significance of postrace decreases in lung function and diffusing capacity, respiratory muscle fatigue, pulmonary edema, biomarkers of cardiac injury, left/right ventricular dysfunction, and chronic myocardial remodeling. The aim of this article is to inform risk stratification for ultra-marathon and to edify best practice for personnel overseeing the events (i.e., race directors and medics).
UR - http://www.scopus.com/inward/record.url?scp=85089302149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089302149&partnerID=8YFLogxK
U2 - 10.1249/JSR.0000000000000738
DO - 10.1249/JSR.0000000000000738
M3 - Article
C2 - 32769665
AN - SCOPUS:85089302149
SN - 1537-890X
VL - 19
SP - 290
EP - 297
JO - Current sports medicine reports
JF - Current sports medicine reports
IS - 8
ER -