Exon shuffling by L1 retrotransposition

John V. Moran, Ralph J. DeBerardinis, Haig H. Kazazian

Research output: Contribution to journalArticle

440 Scopus citations

Abstract

Long interspersed nuclear elements (LINE-1s or L1s) are the most abundant retrotransposons in the human genome, and they serve as major sources of reverse transcriptase activity. Engineered L1s retrotranspose at high frequency in cultured human cells. Here it is shown that L1s insert into transcribed genes and retrotranspose sequences derived from their 3' flanks to new genomic locations. Thus, retrotransposition-competent L1s provide a vehicle to mobilize non-L1 sequences, such as exons or promoters, into existing genes and may represent a general mechanism for the evolution of new genes.

Original languageEnglish (US)
Pages (from-to)1530-1534
Number of pages5
JournalScience
Volume283
Issue number5407
DOIs
StatePublished - Mar 5 1999

ASJC Scopus subject areas

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