TY - JOUR
T1 - Exosomes in cancer development
AU - Stefanius, Karoliina
AU - Servage, Kelly
AU - Orth, Kim
N1 - Funding Information:
We are grateful to Hillery Gray, Genaro Hernandez and Alexander Lafrance for critical reading and for comments of the manuscript and the rest of the members of the Orth lab for their discussions. This work was funded N.I.H. grants R01 GM115188 , Once Upon a Time Foundation and the Welch Foundation I-1561 . Dr. Kim Orth is a Burroughs Welcome Investigator, a Beckman Young Investigator, and a W. W. Caruth, Jr., Biomedical Scholar with an Earl A. Forsythe Chair in Biomedical Science.
Publisher Copyright:
© 2021 Elsevier Ltd
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Exosomes are secreted small extracellular vesicles (EVs) packaged with diverse biological cargo. They mediate complex intercellular communications among cells in maintenance of normal physiology or to trigger profound disease progression. Increasing numbers of studies have identified exosome-mediated functions contributing to cancer progression, including roles in paracrine cell-to-cell communication, stromal reprogramming, angiogenesis, and immune responses. Despite the growing body of knowledge, the specific role of exosomes in mediating pre-cancerous conditions is not fully understood and their ability to transform a healthy cell is still controversial. Here we review recent studies describing functions attributed to exosomes in different stages of carcinogenesis. We also explore how exosomes ultimately contribute to the progression of a primary tumor to metastatic disease.
AB - Exosomes are secreted small extracellular vesicles (EVs) packaged with diverse biological cargo. They mediate complex intercellular communications among cells in maintenance of normal physiology or to trigger profound disease progression. Increasing numbers of studies have identified exosome-mediated functions contributing to cancer progression, including roles in paracrine cell-to-cell communication, stromal reprogramming, angiogenesis, and immune responses. Despite the growing body of knowledge, the specific role of exosomes in mediating pre-cancerous conditions is not fully understood and their ability to transform a healthy cell is still controversial. Here we review recent studies describing functions attributed to exosomes in different stages of carcinogenesis. We also explore how exosomes ultimately contribute to the progression of a primary tumor to metastatic disease.
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U2 - 10.1016/j.gde.2020.12.018
DO - 10.1016/j.gde.2020.12.018
M3 - Review article
C2 - 33477017
AN - SCOPUS:85099532698
VL - 66
SP - 83
EP - 92
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
ER -