Expansion of B cells is necessary for the induction of T-Cell tolerance elicited through the anterior chamber of the eye

Hossam M. Ashour, Jerry Y. Niederkorn

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Antigens injected into the anterior chamber (AC) of the eye induce a form of peripheral immune tolerance termed anterior chamber-associated immune deviation (ACAID). ACAID is initiated by F4/80+ ocular antigen-presenting cells (APC) which capture ocular antigens and migrate to the spleen where they transfer antigenic peptides to B cells, which act as ancillary APC for the induction of T-regulatory cells (Treg) that inhibit delayed-type hypersensitivity (DTH) responses. Here we show that ocular-like APC induce the expansion of tolerogenic splenic B cells. Furthermore, we show that inhibiting B-cell proliferation with either mitomycin-c or γ-irradiation abolishes the ability of B cells to induce Treg. To our knowledge, this is the first study to report that B-cell proliferation is needed for B-cell-induced T-cell tolerance.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalInternational Archives of Allergy and Immunology
Volume144
Issue number4
DOIs
StatePublished - Nov 1 2007

Keywords

  • B cells
  • Immune privilege
  • Peripheral tolerance
  • T-regulatory cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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