Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate

Preston D. Crowell, Jonathan J. Fox, T. Hashimoto, Johnny A. Diaz, Héctor I. Navarro, Gervaise H. Henry, Blake A. Feldmar, Matthew G. Lowe, Alejandro J. Garcia, Ye E. Wu, Dipti P. Sajed, Douglas W Strand, Andrew S. Goldstein

Research output: Contribution to journalArticle

Abstract

Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established. Here we find that organoid-forming progenitor activity of mouse prostate basal and luminal cells is maintained with age. This is caused by an age-related expansion of progenitor-like luminal cells that share features with human prostate luminal progenitor cells. The increase in luminal progenitor cells may contribute to greater risk for growth-related disease in the aging prostate. Importantly, we demonstrate expansion of human luminal progenitor cells in BPH. In summary, we define a Trop2+ luminal progenitor subset and identify an age-related shift in the luminal compartment of the mouse and human prostate epithelium. Aging is a significant risk factor for BPH and prostate cancer, but how aging increases disease risk in the prostate remains poorly defined. Crowell et al. show that progenitor-enriched luminal cells are expanded with aging in the mouse and human prostate, and may contribute to BPH.

Original languageEnglish (US)
Pages (from-to)1499-1510.e6
JournalCell Reports
Volume28
Issue number6
DOIs
StatePublished - Aug 6 2019

Fingerprint

Cell Aging
Prostate
Stem Cells
Aging of materials
Prostatic Hyperplasia
Prostatic Neoplasms
Tissue
Organoids
Adult Stem Cells
Stem cells
Growth
Epithelium
Epithelial Cells

Keywords

  • aging
  • basal
  • epithelium
  • luminal
  • organoid
  • progenitor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Crowell, P. D., Fox, J. J., Hashimoto, T., Diaz, J. A., Navarro, H. I., Henry, G. H., ... Goldstein, A. S. (2019). Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate. Cell Reports, 28(6), 1499-1510.e6. https://doi.org/10.1016/j.celrep.2019.07.007

Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate. / Crowell, Preston D.; Fox, Jonathan J.; Hashimoto, T.; Diaz, Johnny A.; Navarro, Héctor I.; Henry, Gervaise H.; Feldmar, Blake A.; Lowe, Matthew G.; Garcia, Alejandro J.; Wu, Ye E.; Sajed, Dipti P.; Strand, Douglas W; Goldstein, Andrew S.

In: Cell Reports, Vol. 28, No. 6, 06.08.2019, p. 1499-1510.e6.

Research output: Contribution to journalArticle

Crowell, PD, Fox, JJ, Hashimoto, T, Diaz, JA, Navarro, HI, Henry, GH, Feldmar, BA, Lowe, MG, Garcia, AJ, Wu, YE, Sajed, DP, Strand, DW & Goldstein, AS 2019, 'Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate', Cell Reports, vol. 28, no. 6, pp. 1499-1510.e6. https://doi.org/10.1016/j.celrep.2019.07.007
Crowell PD, Fox JJ, Hashimoto T, Diaz JA, Navarro HI, Henry GH et al. Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate. Cell Reports. 2019 Aug 6;28(6):1499-1510.e6. https://doi.org/10.1016/j.celrep.2019.07.007
Crowell, Preston D. ; Fox, Jonathan J. ; Hashimoto, T. ; Diaz, Johnny A. ; Navarro, Héctor I. ; Henry, Gervaise H. ; Feldmar, Blake A. ; Lowe, Matthew G. ; Garcia, Alejandro J. ; Wu, Ye E. ; Sajed, Dipti P. ; Strand, Douglas W ; Goldstein, Andrew S. / Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate. In: Cell Reports. 2019 ; Vol. 28, No. 6. pp. 1499-1510.e6.
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