Experimental anti-GBM nephritis as an analytical tool for studying spontaneous lupus nephritis

Yong Du, Yuyang Fu, Chandra Mohan

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that results in immune-mediated damage to multiple organs. Among these, kidney involvement is the most common and fatal. Spontaneous lupus nephritis (SLN) in mouse models has provided valuable insights into the underlying mechanisms of human lupus nephritis. However, SLN in mouse models takes 6-12 months to manifest; hence there is clearly the need for a mouse model that can be used to unveil the pathogenic processes that lead to immune nephritis over a shorter time frame. In this article more than 25 different molecules are reviewed that have been studied both in the anti-glomerular basement membrane (anti-GBM) model and in SLN and it was found that these molecules influence both diseases in a parallel fashion, suggesting that the two disease settings share common molecular mechanisms. Based on these observations, the authors believe the experimental anti-GBM disease model might be one of the best tools currently available for uncovering the downstream molecular mechanisms leading to SLN.

Original languageEnglish (US)
Pages (from-to)31-40
Number of pages10
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume56
Issue number1
DOIs
StatePublished - Feb 1 2008

Keywords

  • Autoantibodies
  • Glomerular disease
  • Mouse models
  • SLE
  • Therapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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