Experimental arthritis produced by injection of mediators of delayed hypersensitivity

M. Andreis, P. Stastny, M. Ziff

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Synovitis was produced in the rabbit knee by repeated intraarticular injection of a preparation of mediators of cellular immunity. The mediators were prepared by incubation of keyhold limpet hemocyanin with lymph node cells of animals previously immunized with this substance in Freund's adjuvant. Following three intraarticular injections, a chronic synovitis resulted in which hyperplasia of the lining layer and infiltration of the sublining layer occurred. The cell types in the sublining layer were predominantly histiocytes and fibroblasts. These experiments demonstrate that the cellular immune response may play a role in the development of the synovitis of immunologically induced arthritides.

Original languageEnglish (US)
Title of host publicationRHEUM.ANNUAL REV.
Pages303-307
Number of pages5
VolumeVol. 6
StatePublished - 1975

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Experimental Arthritis
Synovitis
Delayed Hypersensitivity
Intra-Articular Injections
Cellular Immunity
Injections
Hemocyanin
Histiocytes
Freund's Adjuvant
Arthritis
Hyperplasia
Knee
Fibroblasts
Lymph Nodes
Rabbits

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Andreis, M., Stastny, P., & Ziff, M. (1975). Experimental arthritis produced by injection of mediators of delayed hypersensitivity. In RHEUM.ANNUAL REV. (Vol. Vol. 6, pp. 303-307)

Experimental arthritis produced by injection of mediators of delayed hypersensitivity. / Andreis, M.; Stastny, P.; Ziff, M.

RHEUM.ANNUAL REV.. Vol. Vol. 6 1975. p. 303-307.

Research output: Chapter in Book/Report/Conference proceedingChapter

Andreis, M, Stastny, P & Ziff, M 1975, Experimental arthritis produced by injection of mediators of delayed hypersensitivity. in RHEUM.ANNUAL REV.. vol. Vol. 6, pp. 303-307.
Andreis M, Stastny P, Ziff M. Experimental arthritis produced by injection of mediators of delayed hypersensitivity. In RHEUM.ANNUAL REV.. Vol. Vol. 6. 1975. p. 303-307
Andreis, M. ; Stastny, P. ; Ziff, M. / Experimental arthritis produced by injection of mediators of delayed hypersensitivity. RHEUM.ANNUAL REV.. Vol. Vol. 6 1975. pp. 303-307
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