Experimental hyperphenylalaninemia: Dendritic alterations in motor cortex of rat

R. N. Hogan, P. D. Coleman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Rats were injected i.p. daily from postnatal days 3 through 82 with a combination of the phenylalanine hydroxylase inhibitor p-chlorophenylalanine (60 mg/kg) plus phenylalanine (300 mg/kg), resulting in a significant hyperphenylalaninemia of 5.36 mg 100 ml. Control rats were saline injected. Golgi-Cox-stained layer V pyramidal and layer IV stellate neurons from cortical area 4 were measured using a computerized dendrite tracking system. Basal and oblique dendritic segments of layer V pyramidal cells in animals with hyperphenylalaninemia were fewer in number, shorter, branched closer to the cell soma or apical shaft, and branched less frequently than did dendrites in control animals. Fewer differences were found for layer IV stellate cells. These data suggest that in human hyperphenylalaninemia which is not severe enough to satisfy the classification criterion for phenylketonuria of 16.5 mg 100 ml plasma there may be undetected alterations in the morphology of cortical dendrites.

Original languageEnglish (US)
Pages (from-to)218-233
Number of pages16
JournalExperimental Neurology
Volume74
Issue number1
DOIs
StatePublished - Oct 1981

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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