@inbook{4b50a34d3ed946a4badab39bc3f0af9c,
title = "Experimental hypoxia as a model for cardiac regeneration in mice",
abstract = "Experimental hypoxia has been used for decades to examine the adaptive response to low-oxygen environments. Various models have been studied, including flies, worms, fish, rodents, and humans. Our lab has recently used this technology to examine the effect of environmental hypoxia on mammalian heart regeneration. In this chapter, we describe studies of systemic hypoxia in mice. We found that systemic hypoxia can blunt oxidative DNA damage and induce cardiomyocyte proliferation. While our primary interests are focused on cardiovascular research, these hypoxia protocols are applicable to any other organ system.",
keywords = "Cardiomyocyte, Heart regeneration, Hypoxia, Mice, Oxygen",
author = "Yuji Nakada and Sadek, {Hesham A.}",
note = "Funding Information: This work is supported by the NIH (grant 1R01HL115275-01) (H.A.S.) and Center for Regenerative Science and Medicine. C.X.S. was partially supported by NIH grant UL1TR001105. A.M.S. is supported by the British Heart Foundation (CH/1999001/11735).",
year = "2021",
doi = "10.1007/978-1-0716-0668-1_25",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "337--344",
booktitle = "Methods in Molecular Biology",
}