Experimental hypoxia as a model for cardiac regeneration in mice

Yuji Nakada, Hesham A. Sadek

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Experimental hypoxia has been used for decades to examine the adaptive response to low-oxygen environments. Various models have been studied, including flies, worms, fish, rodents, and humans. Our lab has recently used this technology to examine the effect of environmental hypoxia on mammalian heart regeneration. In this chapter, we describe studies of systemic hypoxia in mice. We found that systemic hypoxia can blunt oxidative DNA damage and induce cardiomyocyte proliferation. While our primary interests are focused on cardiovascular research, these hypoxia protocols are applicable to any other organ system.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages337-344
Number of pages8
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2158
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Cardiomyocyte
  • Heart regeneration
  • Hypoxia
  • Mice
  • Oxygen

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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