Experimental model simulating right ventricular outflow tract tachycardia: A novel technique to initiate RVOT-VT

Jing Zhou, Benjamin J. Scherlag, William Yamanashi, Richard Wu, Yan Huang, Ralph Lazzara, Warren M. Jackman, Sunny S. Po

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22 Scopus citations

Abstract

A Novel Technique to Initiate RVOT-VT. Objective: To simulate right ventricular outflow tract tachycardia (RVOT-VT) in experimental animals. Background: The mechanism(s) whereby a discrete area of myocardium in the RVOT becomes arrhythmogenic remains unknown. Methods: In 13 dogs, a circular catheter was placed in the proximal pulmonary artery (PA) to contact the endovascular circumference of the PA. A 50-msec train of high-frequency stimulation (HFS, 200 Hz), coupled to atrial pacing, was applied at each bipolar pair of the circular catheter. The coupling interval was adjusted so that the 50-msec train occurred during the ventricular refractory period, that is, the QRS complex, in order to prevent stimulation of the myocardial sleeve within the proximal PA. Results: In all dogs, HFS induced ventricular premature depolarizations and VTs with a left bundle branch block (LBBB) morphology and inferior axis. Earliest activation was consistently recorded from the proximal PA. Esmolol, a short-acting beta-blocker (1 mg/kg), was administered intravenously in 11 dogs. The inducible ventricular ectopy was abolished in 10 dogs and the response to HFS was blunted in one dog (10-11 V). After 30 minutes, the response to HFS returned to pre-esmolol levels. Conclusions: Stimulation of the sympathetic input to the proximal PA induces ventricular ectopy and VTs exhibiting a left bundle branch block morphology and inferior axis, closely simulating clinical RVOT-VT. Beta-blockade either abolishes or blunts this response, corroborating the sympathetic etiology in this model and in some clinical cases of RVOT tachycardias.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalJournal of Cardiovascular Electrophysiology
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 2006

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Keywords

  • Ablation
  • Autonomic nervous system
  • Pulmonary artery
  • Right ventricular outflow tract
  • Sympathetic nerve
  • Ventricular tachycardia
  • Ventromedial cardiac nerve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

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