Experimental subendocardial ischemia during left ventricular hypertension

G. D. Buckberg, J. P. Archie, David E Fixler, J. I E Hoffman

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The increased myocardial oxygen requirements of elevated left ventricular pressure are not adequately met when the left ventricular hypertension alters the factors responsible for subendocardial perfusion. The observed reduction in relative subendocardial flow occurred because high ventricular diastolic pressures impeded it and the duration of diastole was decreased by prolonged systolic ejection times and further shortened by tachycardia. The altered flow distributions were predictable from pressure measurements routinely obtained at cardiac catheterization.

Original languageEnglish (US)
Pages (from-to)124-125
Number of pages2
JournalSurgical forum
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • Surgery


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