Experimental tests of a two-layer Monte Carlo - Diffusion hybrid model for photon migration in the frequency domain

G. W. Faris, G. Alexandrakis, D. R. Busch, M. S. Patterson

Research output: Contribution to journalArticle

1 Scopus citations


We examine the ability to recover the optical properties of a two-layer turbid medium using multi-distance frequency domain reflectance measurements and a hybrid Monte Carlo - diffusion model. Frequency domain measurements are performed on two-layer liquid tissue phantoms simulating skin on muscle and skin on fat. Particular care to systematic effects in the photomultiplier is required for the measurements at short source-detectors distances. The model converges when fitting five free parameters (the optical properties of the upper and lower layers and the upper layer thickness). However, discrepancies between experiment and model yield insufficient accuracy for the absorption coefficicnt of the upper layer.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 1 2001



  • Diffusion equation
  • Frequency domain measurements
  • Monte Carlo simulations
  • Photon migration
  • Tissue optics
  • Tissue-simulating phantoms
  • Two-layer turbid media

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this