Experimentally validated pencil beam scanning source model in TOPAS

Liyong Lin, Minglei Kang, Timothy D. Solberg, Christopher G. Ainsley, James E. McDonough

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The presence of a low-dose envelope, or 'halo', in the fluence profile of a proton spot can increase the output of a pencil beam scanning field by over 10%. This study evaluated whether the Monte Carlo simulation code, TOPAS 1.0-beta 8, based on Geant4.9.6 with its default physics list, can predict the spot halo at depth in phantom by incorporating a halo model within the proton source distribution. Proton sources were modelled using three 2D Gaussian functions, and optimized until simulated spot profiles matched measurements at the phantom surface out to a radius of 100 mm. Simulations were subsequently compared with profiles measured using EBT3 film in Solidwater® phantoms at various depths for 100, 115, 150, 180, 210 and 225 MeV proton beams. Simulations predict measured profiles within a 1 mm distance to agreement for 2D profiles extending to the 0.1% isodose, and within 1 mm/1% Gamma criteria over the integrated curve of spot profile as a function of radius. For isodose lines beyond 0.1% of the central spot dose, the simulated primary spot sigma is smaller than the measurement by up to 15%, and can differ by over 1 mm. The choice of particle interaction algorithm and phantom material were found to cause ∼1 mm range uncertainty, a maximal 5% (0.3 mm) difference in spot sigma, and maximal 1 mm and ∼2 mm distance to agreement in isodoses above and below the 0.1% level, respectively. Based on these observations, therefore, the selection of physics model and the application of Solidwater® as water replacement material in simulation and measurement should be used with caution.

Original languageEnglish (US)
Pages (from-to)6859-6873
Number of pages15
JournalPhysics in medicine and biology
Volume59
Issue number22
DOIs
StatePublished - Nov 21 2014

Keywords

  • Monte Carlo simulation
  • Solidwater®
  • pencil beam scanning
  • proton therapy
  • treatment planning

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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    Lin, L., Kang, M., Solberg, T. D., Ainsley, C. G., & McDonough, J. E. (2014). Experimentally validated pencil beam scanning source model in TOPAS. Physics in medicine and biology, 59(22), 6859-6873. https://doi.org/10.1088/0031-9155/59/22/6859