TY - JOUR
T1 - Exploring cell-based tolerance strategies for hand and face transplantation
AU - Fryer, Madeline
AU - Grahammer, Johanna
AU - Khalifian, Saami
AU - Furtmüller, Georg J.
AU - Lee, W. P.Andrew
AU - Raimondi, Giorgio
AU - Brandacher, Gerald
N1 - Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2015/11/2
Y1 - 2015/11/2
N2 - Broader clinical application of reconstructive hand and face transplantation is hindered by the need for lifelong immunosuppression for allograft maintenance. In this review, we summarize various cell-based approaches to tolerance induction currently under investigation in both clinical and pre-clinical models to alleviate the need for chronic immunosuppression. These include strategies to induce mixed hematopoietic chimerism, therapy with T and B regulatory cells, regulatory macrophages, tolerogenic dendritic cells, and mesenchymal stem cells. The vascularized, intragraft bone components inherent to reconstructive transplants serve as a continuous source of donor-derived hematopoietic cells, and make hand and face transplants uniquely well suited for cell-based approaches to tolerance that may ultimately tilt the risk-benefit balance for these life-changing, but not life-saving, procedures.
AB - Broader clinical application of reconstructive hand and face transplantation is hindered by the need for lifelong immunosuppression for allograft maintenance. In this review, we summarize various cell-based approaches to tolerance induction currently under investigation in both clinical and pre-clinical models to alleviate the need for chronic immunosuppression. These include strategies to induce mixed hematopoietic chimerism, therapy with T and B regulatory cells, regulatory macrophages, tolerogenic dendritic cells, and mesenchymal stem cells. The vascularized, intragraft bone components inherent to reconstructive transplants serve as a continuous source of donor-derived hematopoietic cells, and make hand and face transplants uniquely well suited for cell-based approaches to tolerance that may ultimately tilt the risk-benefit balance for these life-changing, but not life-saving, procedures.
KW - mesenchymal stem cell
KW - mixed chimerism
KW - regulatory B cell
KW - regulatory T cell
KW - regulatory macrophage
KW - tolerance
KW - tolerogenic dendritic cell
KW - vascularized composite allotransplantation
UR - http://www.scopus.com/inward/record.url?scp=84945439817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945439817&partnerID=8YFLogxK
U2 - 10.1586/1744666X.2015.1078729
DO - 10.1586/1744666X.2015.1078729
M3 - Review article
C2 - 26289376
AN - SCOPUS:84945439817
SN - 1744-666X
VL - 11
SP - 1189
EP - 1204
JO - Expert review of clinical immunology
JF - Expert review of clinical immunology
IS - 11
ER -