Exploring polyamine biosynthetic diversity through comparative and functional genomics.

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The existence of multiple, alternative pathways for polyamine biosynthesis, and the presence of alternative polyamine structural analogs, is an indication of the physiological importance of polyamines and their long evolutionary history. Polyamine biosynthesis is modular: diamines are synthesized directly or indirectly from amino acids, and triamines are synthesized from diamines by transfer of aminopropyl, carboxyaminopropyl, or aminobutyl groups to the diamine. Diversification of polyamine biosynthesis has depended on gene duplication and functional divergence, on gene fusion, and on horizontal gene transfer. Four examples of polyamine biosynthetic diversification are presented here with a discussion of methodological and conceptual approaches for identification of new pathways.

Original languageEnglish (US)
Pages (from-to)39-50
Number of pages12
JournalMethods in molecular biology (Clifton, N.J.)
Volume720
DOIs
StatePublished - May 24 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Exploring polyamine biosynthetic diversity through comparative and functional genomics.'. Together they form a unique fingerprint.

  • Cite this