Abstract
(Chemical Equation Presented) A synthetic approach to palau'amine is described that exploits veiled symmetry in the structure. Bis-alkylidenes i have been prepared and found susceptible to halogenative desymmetrization using t-BuOCl. This oxidation forms the imbedded spirocyclopentane motif observed in the natural product. A host of atypical reactions and processes developed during these studies are discussed, as are plans for completing total syntheses of this compound class.
Original language | English (US) |
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Pages (from-to) | 5909-5919 |
Number of pages | 11 |
Journal | Journal of Organic Chemistry |
Volume | 74 |
Issue number | 16 |
DOIs | |
State | Published - 2009 |
ASJC Scopus subject areas
- Organic Chemistry