Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis

Weiguo Zhang; Gary H. Karpen; Qing Zhang

doi:10.1080/15384101.2017.1387698

Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis

Weiguo Zhang, Gary H. Karpen, Qing Zhang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.

Original language	English (US)
Pages (from-to)	2323-2325
Number of pages	3
Journal	Cell Cycle
Volume	16
Issue number	24
DOIs	https://doi.org/10.1080/15384101.2017.1387698
State	Published - Dec 17 2017
Externally published	Yes

Keywords

CENP-A
Cyclin E1
FBW7
centromere
chromosome instability
tumorigenesis

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.1080/15384101.2017.1387698

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title = "Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis",

abstract = "Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.",

keywords = "CENP-A, Cyclin E1, FBW7, centromere, chromosome instability, tumorigenesis",

author = "Weiguo Zhang and Karpen, {Gary H.} and Qing Zhang",

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year = "2017",

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doi = "10.1080/15384101.2017.1387698",

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AU - Zhang, Weiguo

AU - Karpen, Gary H.

AU - Zhang, Qing

PY - 2017/12/17

Y1 - 2017/12/17

N2 - Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.

AB - Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.

KW - CENP-A

KW - Cyclin E1

KW - FBW7

KW - centromere

KW - chromosome instability

KW - tumorigenesis

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SN - 1538-4101

VL - 16

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EP - 2325

JO - Cell Cycle

JF - Cell Cycle

IS - 24

ER -

Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

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