Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis

Weiguo Zhang, Gary H. Karpen, Qing Zhang

Research output: Contribution to journalArticle

Abstract

Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.

Original languageEnglish (US)
Pages (from-to)2323-2325
Number of pages3
JournalCell Cycle
Volume16
Issue number24
DOIs
StatePublished - Dec 17 2017

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Keywords

  • CENP-A
  • Cyclin E1
  • FBW7
  • centromere
  • chromosome instability
  • tumorigenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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