Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice

Ralph L. Brinster, Kindred A. Ritchie, Robert E Hammer, Rebecca L. O'Brien, Benjamin Arp, Ursula Storb

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Abstract

Transgenic mice were produced by microinjection of a rearranged, functional immunoglobulin κ gene into fertilized mouse eggs and implantation of the microinjected embryos into foster mothers. Mice that integrated the injected gene were mated and the DNA, RNA and serum κ chains of their offspring were analysed. The data from offspring of three different transgenic mice indicate that the microinjected gene is expressed in the spleen, but not the liver of mice which inherited the injected gene.

Original languageEnglish (US)
Pages (from-to)332-336
Number of pages5
JournalNature
Volume306
Issue number5941
DOIs
StatePublished - Dec 1 1983

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    Brinster, R. L., Ritchie, K. A., Hammer, R. E., O'Brien, R. L., Arp, B., & Storb, U. (1983). Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice. Nature, 306(5941), 332-336. https://doi.org/10.1038/306332a0