Expression of a mutant androgen receptor in cloned fibroblasts derived from a heterozygous carrier for the syndrome of testicular feminization

M. K. Elawady, D. R. Allman, J. E. Griffin, J. D. Wilson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Thermolability of androgen binding was compared in fiboblasts cloned from normal female skin, skin from a subject with testicular feminization whose mutation is known to be associated with a thermolabile androgen receptor, and from the mother of the subject with testicular feminization. Seven of 28 clones studied from the mother exhibited thermolability of binding, indicating that the mutant gene that causes thermolability of binding, like the gene responsible for the normal androgen receptor, is X-linked.

Original languageEnglish (US)
Pages (from-to)376-384
Number of pages9
JournalAmerican Journal of Human Genetics
Volume35
Issue number3
StatePublished - 1983

Fingerprint

Androgen-Insensitivity Syndrome
Androgen Receptors
Fibroblasts
Skin
Androgens
Genes
Clone Cells
Mutation

ASJC Scopus subject areas

  • Genetics

Cite this

Expression of a mutant androgen receptor in cloned fibroblasts derived from a heterozygous carrier for the syndrome of testicular feminization. / Elawady, M. K.; Allman, D. R.; Griffin, J. E.; Wilson, J. D.

In: American Journal of Human Genetics, Vol. 35, No. 3, 1983, p. 376-384.

Research output: Contribution to journalArticle

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