Expression of an immunoglobulin heavy chain transgene in macrophage as well as lymphocyte lineages in vivo

Chandrashekhar Pasare, Scott Noggle, Maureen Entringer, Andrew Heinzelmann, Pratima Bansal, Anna George, Vineeta Bal, Satyajit Rath, Jeannine M. Durdik

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A rearranged immunoglobulin heavy chain (IgH) transgene-encoded protein is expressed in macrophage lineage cells, in addition to B and T lineages, in transgenic mouse bone marrow. Peripheral macrophages also express transgenic IgH protein. Mature T cells express lower levels than immature thymocytes. Almost all B220+ cells in the bone marrow express transgenic IgH protein, and this early expression in the B lineage is accompanied by a reduction of cell frequency even in the early B220+ CD43+ BP-1- stages, although it is more prominent in BP-1+ pre-B cells. Thus, an IgH transgene can be expressed not only in lymphoid but also in myeloid cells, although its developmental effects are restricted to the B cell lineage.

Original languageEnglish (US)
Pages (from-to)1219-1227
Number of pages9
JournalEuropean Journal of Immunology
Volume29
Issue number4
DOIs
StatePublished - Jan 1 1999

Keywords

  • B cell development
  • IgH enhancer
  • Macrophage
  • T cell
  • Transgenic mouse

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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