Abstract
A rearranged immunoglobulin heavy chain (IgH) transgene-encoded protein is expressed in macrophage lineage cells, in addition to B and T lineages, in transgenic mouse bone marrow. Peripheral macrophages also express transgenic IgH protein. Mature T cells express lower levels than immature thymocytes. Almost all B220+ cells in the bone marrow express transgenic IgH protein, and this early expression in the B lineage is accompanied by a reduction of cell frequency even in the early B220+ CD43+ BP-1- stages, although it is more prominent in BP-1+ pre-B cells. Thus, an IgH transgene can be expressed not only in lymphoid but also in myeloid cells, although its developmental effects are restricted to the B cell lineage.
Original language | English (US) |
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Pages (from-to) | 1219-1227 |
Number of pages | 9 |
Journal | European Journal of Immunology |
Volume | 29 |
Issue number | 4 |
DOIs | |
State | Published - 1999 |
Keywords
- B cell development
- IgH enhancer
- Macrophage
- T cell
- Transgenic mouse
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology