Expression of bcl-2 in small cell lung carcinoma cells

Naohiko Ikegaki, Makoto Katsumata, John Minna, Yoshihide Tsujimoto

Research output: Contribution to journalArticle

209 Scopus citations

Abstract

We have investigated the expression of bcl-2 protein in a panel of small cell lung carcinoma (SCLC) cells lines. Five of six cell lines examined expressed relatively high levels of bcl-2 protein and transcripts. The bcl-2 expression in SCLC cells, however, was not always associated with myc expression. Since dysregulation of bcl-2 may be involved in the course of tumorigenesis and/or in the acquisition of drug resistance of tumor cells, the expression of bcl-2 in SCLC cells may become an important indicator in the prognosis or treatment of SCLC.

Original languageEnglish (US)
Pages (from-to)6-8
Number of pages3
JournalCancer Research
Volume54
Issue number1
Publication statusPublished - Jan 1 1994

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ikegaki, N., Katsumata, M., Minna, J., & Tsujimoto, Y. (1994). Expression of bcl-2 in small cell lung carcinoma cells. Cancer Research, 54(1), 6-8.