Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human

Predominance of gec1/GABARAPL1 in the central nervous system

Christophe Nemos, Virginie Mansuy, Sandrine Vernier-Magnin, Annick Fraichard, Michèle Jouvenot, R. égis Delage-Mourroux

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA A receptors on post-synaptic membrane of neurons. Using specific cDNA probes, we investigated the differential expression of both genes in 76 human tissues. Against all odds, gec1/GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands.

Original languageEnglish (US)
Pages (from-to)216-219
Number of pages4
JournalMolecular Brain Research
Volume119
Issue number2
DOIs
StatePublished - Nov 26 2003

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Central Nervous System
Endocrine Glands
Synaptic Membranes
Messenger RNA
Microtubule-Associated Proteins
GABA-A Receptors
Cluster Analysis
Proteins
Complementary DNA
Gene Expression
Neurons
Genes

Keywords

  • Central nervous system
  • GABARAP
  • gec1/GABARAPL1
  • Gene expression
  • Human
  • Macroarray

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human : Predominance of gec1/GABARAPL1 in the central nervous system. / Nemos, Christophe; Mansuy, Virginie; Vernier-Magnin, Sandrine; Fraichard, Annick; Jouvenot, Michèle; Delage-Mourroux, R. égis.

In: Molecular Brain Research, Vol. 119, No. 2, 26.11.2003, p. 216-219.

Research output: Contribution to journalArticle

Nemos, Christophe ; Mansuy, Virginie ; Vernier-Magnin, Sandrine ; Fraichard, Annick ; Jouvenot, Michèle ; Delage-Mourroux, R. égis. / Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human : Predominance of gec1/GABARAPL1 in the central nervous system. In: Molecular Brain Research. 2003 ; Vol. 119, No. 2. pp. 216-219.
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