TY - JOUR
T1 - Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human
T2 - Predominance of gec1/GABARAPL1 in the central nervous system
AU - Nemos, Christophe
AU - Mansuy, Virginie
AU - Vernier-Magnin, Sandrine
AU - Fraichard, Annick
AU - Jouvenot, Michèle
AU - Delage-Mourroux, R. égis
N1 - Funding Information:
This research work was supported by a fellowship from the Région of Franche-Comté and by grants from the Ministère de l′ Enseignement Supérieur et de la Recherche (E.A. 3182) and the Ligue Nationale Contre le Cancer (Comité du Doubs and Comité du Jura). We thank Dr. Ramji Rajendran for reviewing the English.
PY - 2003/11/26
Y1 - 2003/11/26
N2 - GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA A receptors on post-synaptic membrane of neurons. Using specific cDNA probes, we investigated the differential expression of both genes in 76 human tissues. Against all odds, gec1/GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands.
AB - GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA A receptors on post-synaptic membrane of neurons. Using specific cDNA probes, we investigated the differential expression of both genes in 76 human tissues. Against all odds, gec1/GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands.
KW - Central nervous system
KW - GABARAP
KW - Gene expression
KW - Human
KW - Macroarray
KW - gec1/GABARAPL1
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UR - http://www.scopus.com/inward/citedby.url?scp=0242475153&partnerID=8YFLogxK
U2 - 10.1016/j.molbrainres.2003.09.011
DO - 10.1016/j.molbrainres.2003.09.011
M3 - Article
C2 - 14625090
AN - SCOPUS:0242475153
SN - 0169-328X
VL - 119
SP - 216
EP - 219
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -