Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human: Predominance of gec1/GABARAPL1 in the central nervous system

Christophe Nemos, Virginie Mansuy, Sandrine Vernier-Magnin, Annick Fraichard, Michèle Jouvenot, R. égis Delage-Mourroux

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA A receptors on post-synaptic membrane of neurons. Using specific cDNA probes, we investigated the differential expression of both genes in 76 human tissues. Against all odds, gec1/GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands.

Original languageEnglish (US)
Pages (from-to)216-219
Number of pages4
JournalMolecular Brain Research
Volume119
Issue number2
DOIs
StatePublished - Nov 26 2003

Keywords

  • Central nervous system
  • GABARAP
  • Gene expression
  • Human
  • Macroarray
  • gec1/GABARAPL1

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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