TY - JOUR
T1 - Expression of hyaluronidase by tumor cells induces angiogenesis in vivo
AU - Liu, Dacai
AU - Pearlman, Eric
AU - Diaconu, Eugenia
AU - Guo, Kun
AU - Mori, Hiroshi
AU - Haqqi, Tariq
AU - Markowitz, Sanford
AU - Willson, James
AU - Sy, Man Sun
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1996/7/23
Y1 - 1996/7/23
N2 - Hyaluronic acid is a proteoglycan present in the extracellular matrix and is important for the maintenance of tissue architecture. Depolymerization of hyaluronic acid may facilitate tumor invasion. In addition, oligosaccharides of hyaluronic acid have been reported to induce angiogenesis. We report here that a hyaluronidase similar to the one on human sperm is expressed by metastatic human melanoma, colon carcinoma, and glioblastoma cell lines and by tumor biopsies from patients with colorectal carcinomas, but not by tissues from normal colon. Moreover, angiogenesis is induced by hyaluronidase+ tumor cells but not hyaluronidase- tumor cells and can be blocked by an inhibitor of hyaluronidase. Tumor cells thus use hyaluronidase as one of the 'molecular saboteurs' to depolymerize hyaluronic acid to facilitate invasion. As a consequence, breakdown products of hyaluronic acid can further promote tumor establishment by inducing angiogenesis. Hyaluronidase on tumor cells may provide a target for anti- neoplastic drugs.
AB - Hyaluronic acid is a proteoglycan present in the extracellular matrix and is important for the maintenance of tissue architecture. Depolymerization of hyaluronic acid may facilitate tumor invasion. In addition, oligosaccharides of hyaluronic acid have been reported to induce angiogenesis. We report here that a hyaluronidase similar to the one on human sperm is expressed by metastatic human melanoma, colon carcinoma, and glioblastoma cell lines and by tumor biopsies from patients with colorectal carcinomas, but not by tissues from normal colon. Moreover, angiogenesis is induced by hyaluronidase+ tumor cells but not hyaluronidase- tumor cells and can be blocked by an inhibitor of hyaluronidase. Tumor cells thus use hyaluronidase as one of the 'molecular saboteurs' to depolymerize hyaluronic acid to facilitate invasion. As a consequence, breakdown products of hyaluronic acid can further promote tumor establishment by inducing angiogenesis. Hyaluronidase on tumor cells may provide a target for anti- neoplastic drugs.
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U2 - 10.1073/pnas.93.15.7832
DO - 10.1073/pnas.93.15.7832
M3 - Article
C2 - 8755562
AN - SCOPUS:0029817452
SN - 0027-8424
VL - 93
SP - 7832
EP - 7837
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 15
ER -