Abstract
In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-I), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-111 |
| Number of pages | 7 |
| Journal | Journal of the Neurological Sciences |
| Volume | 106 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1991 |
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Keywords
- Alzheimer's disease
- Endothelium
- Intercellular adhesion molecule-1
- Lymphocyte function-associated antigen-1
- Neuritic plaque
ASJC Scopus subject areas
- Aging
- Clinical Neurology
- Surgery
- Neuroscience(all)
- Developmental Neuroscience
- Neurology
Cite this
Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease. / Frohman, Elliot; Frohman, Teresa C.; Gupta, Sudhir; de Fougerolles, Antonin; van den Noort, Stanley.
In: Journal of the Neurological Sciences, Vol. 106, No. 1, 1991, p. 105-111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease
AU - Frohman, Elliot
AU - Frohman, Teresa C.
AU - Gupta, Sudhir
AU - de Fougerolles, Antonin
AU - van den Noort, Stanley
PY - 1991
Y1 - 1991
N2 - In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-I), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.
AB - In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-I), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.
KW - Alzheimer's disease
KW - Endothelium
KW - Intercellular adhesion molecule-1
KW - Lymphocyte function-associated antigen-1
KW - Neuritic plaque
UR - http://www.scopus.com/inward/record.url?scp=0025938590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025938590&partnerID=8YFLogxK
U2 - 10.1016/0022-510X(91)90202-I
DO - 10.1016/0022-510X(91)90202-I
M3 - Article
C2 - 1685745
AN - SCOPUS:0025938590
VL - 106
SP - 105
EP - 111
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1
ER -