TY - JOUR
T1 - Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease
AU - Frohman, Elliot
AU - Frohman, Teresa C.
AU - Gupta, Sudhir
AU - de Fougerolles, Antonin
AU - van den Noort, Stanley
N1 - Funding Information:
Acknowledgements We would like to thank Dr. lim Springer and Dr. Michael Dustin for their generous contribution of RR1/I. We would like to thank Dr. Wallace Tourtellotte and the National Neurological Research Bank, Drs. C.arl Cotman and James Geddes, and Dr. Patrick McGeer for the contribution of brain specimens. We also thank Dr. Ben Choi for his contribution of LN-2 antibody and Dr. James Hildreth for the contribution of LFA-I antibody. This work was supported in part by NIA AG00538.
PY - 1991/11
Y1 - 1991/11
N2 - In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-I), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.
AB - In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-I), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.
KW - Alzheimer's disease
KW - Endothelium
KW - Intercellular adhesion molecule-1
KW - Lymphocyte function-associated antigen-1
KW - Neuritic plaque
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U2 - 10.1016/0022-510X(91)90202-I
DO - 10.1016/0022-510X(91)90202-I
M3 - Article
C2 - 1685745
AN - SCOPUS:0025938590
SN - 0022-510X
VL - 106
SP - 105
EP - 111
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1
ER -