Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease

Elliot Frohman, Teresa C. Frohman, Sudhir Gupta, Antonin de Fougerolles, Stanley van den Noort

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-I), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalJournal of the Neurological Sciences
Volume106
Issue number1
DOIs
StatePublished - Nov 1991

Keywords

  • Alzheimer's disease
  • Endothelium
  • Intercellular adhesion molecule-1
  • Lymphocyte function-associated antigen-1
  • Neuritic plaque

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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