TY - JOUR
T1 - Expression of P27(kip1) and ki-67 in pituitary adenomas
T2 - An investigation of marker of adenoma invasiveness
AU - Zhao, D.
AU - Tomono, Y.
AU - Nose, T.
AU - Luedecke, D.
AU - Buchfelder, M.
AU - Fahlbusch, R.
PY - 1999
Y1 - 1999
N2 - Mirroring the ambiguities noted with other endocrine tumours, histology is a poor predictor of the invasiveness of pituitary adenomas. Accordingly, the proteins p77(Kip1) (p27) and Ki-67, which respectively block cell-cycle progression and reflect proliferative activity of cells, were studied immunohistochemically in 123 specimens of pituitary adenomas including 57 clinically verified invasive cases. Only Ki-67 had a significant association with invasiveness; only p27 differed significantly between functioning and nonfunctioning adenomas, with a higher frequency of cell labelling in the former. No relationship between Ki-67 and p27 was obtained. Ki-67 detected by MIB-1 is thus an important marker related to the invasive potential of adenomas, and thereby may be helpful in planning postoperative management of patients with pituitary adenomas.
AB - Mirroring the ambiguities noted with other endocrine tumours, histology is a poor predictor of the invasiveness of pituitary adenomas. Accordingly, the proteins p77(Kip1) (p27) and Ki-67, which respectively block cell-cycle progression and reflect proliferative activity of cells, were studied immunohistochemically in 123 specimens of pituitary adenomas including 57 clinically verified invasive cases. Only Ki-67 had a significant association with invasiveness; only p27 differed significantly between functioning and nonfunctioning adenomas, with a higher frequency of cell labelling in the former. No relationship between Ki-67 and p27 was obtained. Ki-67 detected by MIB-1 is thus an important marker related to the invasive potential of adenomas, and thereby may be helpful in planning postoperative management of patients with pituitary adenomas.
KW - Immunohistochemically
KW - Invasiveness
KW - Ki-67
KW - p27(Kip1)
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U2 - 10.1007/s007010050285
DO - 10.1007/s007010050285
M3 - Article
C2 - 10189502
AN - SCOPUS:0032610766
SN - 0001-6268
VL - 141
SP - 187
EP - 192
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
IS - 2
ER -