Expression of P27(kip1) and ki-67 in pituitary adenomas: An investigation of marker of adenoma invasiveness

D. Zhao, Y. Tomono, T. Nose, D. Luedecke, M. Buchfelder, R. Fahlbusch

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47 Scopus citations


Mirroring the ambiguities noted with other endocrine tumours, histology is a poor predictor of the invasiveness of pituitary adenomas. Accordingly, the proteins p77(Kip1) (p27) and Ki-67, which respectively block cell-cycle progression and reflect proliferative activity of cells, were studied immunohistochemically in 123 specimens of pituitary adenomas including 57 clinically verified invasive cases. Only Ki-67 had a significant association with invasiveness; only p27 differed significantly between functioning and nonfunctioning adenomas, with a higher frequency of cell labelling in the former. No relationship between Ki-67 and p27 was obtained. Ki-67 detected by MIB-1 is thus an important marker related to the invasive potential of adenomas, and thereby may be helpful in planning postoperative management of patients with pituitary adenomas.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalActa Neurochirurgica
Issue number2
StatePublished - Jan 1 1999



  • Immunohistochemically
  • Invasiveness
  • Ki-67
  • p27(Kip1)

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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