Expresión de p53 en el carcinoma gástrico. Su valor pronóstico.

Translated title of the contribution: Expression of p53 in gastric carcinoma. Prognostic value

A. Sundblad, E. M. Pellicer, P. Mehta, C. Ahn, H. Battifora

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

P53 gene mutation has been described with variable frequency in gastric cancer and its biological significance remains unclear. We studied 101 gastric carcinomas to evaluate the association between this genetic alteration and the evolution of gastric cancer. Of these, 67 patients were men and 34 were women. The median age at diagnosis was 68 years. The tumors were obtained from gastrectomies. The p53 gene mutation was determined with the monoclonal antibody DO7 (Novocastra). The neoplasms were classified as tumors with high or low level p53 expression according to the intensity and distribution of the nuclear staining. Forty eight tumors showed high level of p53 immunoreactivity. The association of p53 expression with age, sex, tumor size, histologic type, histologic grade, depth of invasion, localization, lymph node metastases, type of surgery and 5 year survival rate was investigated. The results did not demonstrate any significant association between p53 expression and the factors mentioned above.

Original languageSpanish
Pages (from-to)216-220
Number of pages5
JournalMedicina
Volume54
Issue number3
StatePublished - 1994

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Stomach
Carcinoma
p53 Genes
Neoplasms
Stomach Neoplasms
Mutation
Molecular Evolution
Gastrectomy
Survival Rate
Lymph Nodes
Monoclonal Antibodies
Staining and Labeling
Neoplasm Metastasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sundblad, A., Pellicer, E. M., Mehta, P., Ahn, C., & Battifora, H. (1994). Expresión de p53 en el carcinoma gástrico. Su valor pronóstico. Medicina, 54(3), 216-220.

Expresión de p53 en el carcinoma gástrico. Su valor pronóstico. / Sundblad, A.; Pellicer, E. M.; Mehta, P.; Ahn, C.; Battifora, H.

In: Medicina, Vol. 54, No. 3, 1994, p. 216-220.

Research output: Contribution to journalArticle

Sundblad, A, Pellicer, EM, Mehta, P, Ahn, C & Battifora, H 1994, 'Expresión de p53 en el carcinoma gástrico. Su valor pronóstico.', Medicina, vol. 54, no. 3, pp. 216-220.
Sundblad A, Pellicer EM, Mehta P, Ahn C, Battifora H. Expresión de p53 en el carcinoma gástrico. Su valor pronóstico. Medicina. 1994;54(3):216-220.
Sundblad, A. ; Pellicer, E. M. ; Mehta, P. ; Ahn, C. ; Battifora, H. / Expresión de p53 en el carcinoma gástrico. Su valor pronóstico. In: Medicina. 1994 ; Vol. 54, No. 3. pp. 216-220.
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