Expression of survivin and apoptotic biomarkers in benign prostatic hyperplasia

Shahrokh F. Shariat, Raheela Ashfaq, Claus Roehrborn, Kevin M. Slawin, Yair Lotan

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Purpose: We assessed the differential expression of survivin and other apoptotic markers in stromal and epithelial compartments of benign prostatic hyperplasia (BPH) and normal prostate tissue. Materials and Methods: Immunohistochemical staining for survivin, and transforming growth factor-β1 and its receptors was done in normal prostate and BPH areas from 114 consecutive patients who underwent radical prostatectomy. Moreover, staining for survivin, Bcl-2, Bax, caspase-3 and Ki-67 was performed in prostate specimens from 23 consecutive patients who underwent open prostatectomy and 4 young patients who underwent cystoprostatectomy and had a normal prostate. Results: Survivin and Bcl-2 expression increased incrementally from normal prostate to epithelial BPH to stromal BPH. Caspase-3 expression was higher in BPH epithelium than in BPH stroma, which in turn was higher than that in normal prostate. Ki-67 was significantly over expressed in BPH stroma and epithelium. Survivin expression in BPH tissue correlated with International Prostate Symptom Score, quality of life, post-void residual urine volume, maximum urine flow rate and transforming growth factor-β1 expression. Conclusions: Survivin is over expressed in BPH and it correlates with BPH parameters. Increases in proliferation and inhibition of apoptosis have a role in BPH.

Original languageEnglish (US)
Pages (from-to)2046-2050
Number of pages5
JournalJournal of Urology
Volume174
Issue number5
DOIs
StatePublished - Nov 2005

Keywords

  • Apoptosis
  • Cell proliferation
  • Prostate
  • Prostatic hyperplasia
  • Survivin protein, human

ASJC Scopus subject areas

  • Urology

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