Expression of the neu Gene-encoded Protein (P185neu) in Human Non-Small Cell Carcinomas of the Lung

David B. Weiner, Joanne Nordberg, Robert Robinson, Peter C. Nowell, Adi Gazdar, Mark I. Greene, William V. Williams, Jeffrey A. Cohen, Jeffrey A. Kern

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221 Scopus citations

Abstract

The neu protooncogene is a recently described transforming gene originally isolated from ethylnitrosourea-induced rat neuroblastomas. We have examined the expression of the neu gene in human non-small cell lung carcinomas using immunoprecipitation and immunohistochemistry. The neu protein product (pl85M) was present in eight of 22 non-small cell carcinoma cell lines derived from human lung tumors. Expression of P185 was found in all histological subtypes of non-small cell carcinomas including large cell carcinomas, squamous cell carcinomas, and adenocarcinomas. Extension of these data to biopsy specimens of human lung tumors demonstrated that normal ciliated bronchial epithelium of the peripheral airways expressed P185 at low levels. Neoplastic cells in four of 12 adenocarcinomas and three of five squamous cell carcinomas also expressed pi85 at levels higher than the normal ciliated bronchial epithelium. Together these studies indicate that pi85 expression is a common feature of human lung tumors.

Original languageEnglish (US)
Pages (from-to)421-425
Number of pages5
JournalCancer research
Volume50
Issue number2
StatePublished - Jan 15 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Weiner, D. B., Nordberg, J., Robinson, R., Nowell, P. C., Gazdar, A., Greene, M. I., Williams, W. V., Cohen, J. A., & Kern, J. A. (1990). Expression of the neu Gene-encoded Protein (P185neu) in Human Non-Small Cell Carcinomas of the Lung. Cancer research, 50(2), 421-425.