Expression of the RNA component of telomerase during human development and differentiation

Kazuo Yashima, Anirban Maitra, Beverly Barton Rogers, Charles F. Timmons, Asha Rathi, Halit Pinar, Woodring E. Wright, Jerry W. Shay, Adi F. Gazdar

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We used a radioactive in situ method to study expression of the RNA component of human telomerase (hTR) during normal human development and differentiation using archival tissues. In embryonic tissues, the highest and most uniform expression was present in undifferentiated neuroepithelium. Expression was stronger in immature epithelium than in accompanying immature mesenchyme. Differentiation of most tissues was accompanied by decreased or absent expression. Except for testis and adrenal, the adult pattern of expression was present by the loth postnatal week. In adult tissues, high expression was present in the testis (primary spermatocytes and Sertoli cells), moderate expression was present in lymphoid follicles (germinal centers), and weak expression was present in epithelia (regenerative cells) but was absent in the nervous system and mesenchymal derived tissues. Expression in adult tissues was predominantly limited to dividing cells, although certain differentiated postmitotic cells expressed the hTR. Our studies demonstrate the complex interrelationship of hTR expression with human development, differentiation, and cell division.

Original languageEnglish (US)
Pages (from-to)805-813
Number of pages9
JournalCell Growth and Differentiation
Volume9
Issue number9
StatePublished - Sep 1998

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Human Development
Telomerase
Testis
Epithelium
Spermatocytes
Germinal Center
Sertoli Cells
Mesoderm
Cell Division
Nervous System
telomerase RNA

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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Expression of the RNA component of telomerase during human development and differentiation. / Yashima, Kazuo; Maitra, Anirban; Rogers, Beverly Barton; Timmons, Charles F.; Rathi, Asha; Pinar, Halit; Wright, Woodring E.; Shay, Jerry W.; Gazdar, Adi F.

In: Cell Growth and Differentiation, Vol. 9, No. 9, 09.1998, p. 805-813.

Research output: Contribution to journalArticle

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AU - Rathi, Asha

AU - Pinar, Halit

AU - Wright, Woodring E.

AU - Shay, Jerry W.

AU - Gazdar, Adi F.

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