Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen

Larn Yuan Hwang, Mark Siegelman, Laurie Davis, Nancy Oppenheimer-Marks, Richard Baer

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The TAL1 proto-oncogene encodes a basic helix-loop-helix (bHLH) protein that has been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia. Normal expression of TAL1 is observed in erythrocytic, megakaryocytic and mastocytic cells of the hematopoietic lineage. We now report that both RNA transcripts and polypeptide products of TAL1 are present in human umbilical vein endothelial cells cultured in vitro. Moreover, in situ hybridization revealed a restricted pattern of TAL1 expression in endothelial cells in vivo, including vessels within the white pulp and follicles of the spleen. In view of its presumptive role as a transcriptional factor, the TAL1 gene product may serve during normal development as a regulator of endothelial cell growth or differentiation.

Original languageEnglish (US)
Pages (from-to)3043-3046
Number of pages4
JournalOncogene
Volume8
Issue number11
StatePublished - Nov 1993

Fingerprint

Proto-Oncogenes
Blood Vessels
Cultured Cells
Spleen
Endothelial Cells
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Human Umbilical Vein Endothelial Cells
Cell Lineage
In Situ Hybridization
RNA
Peptides
Growth
Genes
Proteins
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Hwang, L. Y., Siegelman, M., Davis, L., Oppenheimer-Marks, N., & Baer, R. (1993). Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. Oncogene, 8(11), 3043-3046.

Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. / Hwang, Larn Yuan; Siegelman, Mark; Davis, Laurie; Oppenheimer-Marks, Nancy; Baer, Richard.

In: Oncogene, Vol. 8, No. 11, 11.1993, p. 3043-3046.

Research output: Contribution to journalArticle

Hwang, LY, Siegelman, M, Davis, L, Oppenheimer-Marks, N & Baer, R 1993, 'Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen', Oncogene, vol. 8, no. 11, pp. 3043-3046.
Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R. Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. Oncogene. 1993 Nov;8(11):3043-3046.
Hwang, Larn Yuan ; Siegelman, Mark ; Davis, Laurie ; Oppenheimer-Marks, Nancy ; Baer, Richard. / Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. In: Oncogene. 1993 ; Vol. 8, No. 11. pp. 3043-3046.
@article{00836055fffe4c0688b0018d75851d22,
title = "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen",
abstract = "The TAL1 proto-oncogene encodes a basic helix-loop-helix (bHLH) protein that has been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia. Normal expression of TAL1 is observed in erythrocytic, megakaryocytic and mastocytic cells of the hematopoietic lineage. We now report that both RNA transcripts and polypeptide products of TAL1 are present in human umbilical vein endothelial cells cultured in vitro. Moreover, in situ hybridization revealed a restricted pattern of TAL1 expression in endothelial cells in vivo, including vessels within the white pulp and follicles of the spleen. In view of its presumptive role as a transcriptional factor, the TAL1 gene product may serve during normal development as a regulator of endothelial cell growth or differentiation.",
author = "Hwang, {Larn Yuan} and Mark Siegelman and Laurie Davis and Nancy Oppenheimer-Marks and Richard Baer",
year = "1993",
month = "11",
language = "English (US)",
volume = "8",
pages = "3043--3046",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen

AU - Hwang, Larn Yuan

AU - Siegelman, Mark

AU - Davis, Laurie

AU - Oppenheimer-Marks, Nancy

AU - Baer, Richard

PY - 1993/11

Y1 - 1993/11

N2 - The TAL1 proto-oncogene encodes a basic helix-loop-helix (bHLH) protein that has been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia. Normal expression of TAL1 is observed in erythrocytic, megakaryocytic and mastocytic cells of the hematopoietic lineage. We now report that both RNA transcripts and polypeptide products of TAL1 are present in human umbilical vein endothelial cells cultured in vitro. Moreover, in situ hybridization revealed a restricted pattern of TAL1 expression in endothelial cells in vivo, including vessels within the white pulp and follicles of the spleen. In view of its presumptive role as a transcriptional factor, the TAL1 gene product may serve during normal development as a regulator of endothelial cell growth or differentiation.

AB - The TAL1 proto-oncogene encodes a basic helix-loop-helix (bHLH) protein that has been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia. Normal expression of TAL1 is observed in erythrocytic, megakaryocytic and mastocytic cells of the hematopoietic lineage. We now report that both RNA transcripts and polypeptide products of TAL1 are present in human umbilical vein endothelial cells cultured in vitro. Moreover, in situ hybridization revealed a restricted pattern of TAL1 expression in endothelial cells in vivo, including vessels within the white pulp and follicles of the spleen. In view of its presumptive role as a transcriptional factor, the TAL1 gene product may serve during normal development as a regulator of endothelial cell growth or differentiation.

UR - http://www.scopus.com/inward/record.url?scp=0027494965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027494965&partnerID=8YFLogxK

M3 - Article

C2 - 8414504

AN - SCOPUS:0027494965

VL - 8

SP - 3043

EP - 3046

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 11

ER -