Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development

Dionisio Martin-Zanca, Mariano Barbacid, Luis F. Parada

Research output: Contribution to journalArticle

279 Citations (Scopus)

Abstract

We have cloned and characterized the mouse homolog of the human trk proto-oncogene, a member of the protein tyrosine kinase (TK) receptor gene family. Here, we present the first report of a trk-encoded mRNA species in vivo. In situ hybridization analysis in the mouse embryo reveals a striking temporal and spatial regulation of trk transcription, with expression confined to the sensory cranial (trigeminal, superior, jugular) and dorsal root ganglia (DRG) of neural crest origin. Recent reports have shown that TK receptors can play regulatory roles in embryonic development. Thus, the developmental mutations W in mouse and torso and sevenless in Drosophila represent genes that code for defective TK receptors. Our data show that trk, a gene associated with malignancy in humans, is a specific marker for a set of neural crest-derived sensory neurons, and are consistent with the hypothesis that this proto-oncogene may have an important role in the development or phenotype of the neurons where it is expressed.

Original languageEnglish (US)
Pages (from-to)683-694
Number of pages12
JournalGenes and Development
Volume4
Issue number5
StatePublished - 1990

Fingerprint

Sensory Ganglia
Proto-Oncogenes
Neural Crest
Spinal Ganglia
Receptor Protein-Tyrosine Kinases
Genes
Torso
Sensory Receptor Cells
Drosophila
Embryonic Development
In Situ Hybridization
Neck
Embryonic Structures
Phenotype
Neurons
Messenger RNA
Mutation
Neoplasms

Keywords

  • Developmental expression
  • In situ hybridization
  • Proto-oncogene
  • Trk
  • Tyrosine kinase receptor

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. / Martin-Zanca, Dionisio; Barbacid, Mariano; Parada, Luis F.

In: Genes and Development, Vol. 4, No. 5, 1990, p. 683-694.

Research output: Contribution to journalArticle

Martin-Zanca, Dionisio ; Barbacid, Mariano ; Parada, Luis F. / Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. In: Genes and Development. 1990 ; Vol. 4, No. 5. pp. 683-694.
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