Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis

David Sassoon, Gary Lyons, Woodring E. Wright, Victor Lin, Andrew Lassar, Harold Weintraub, Margaret Buckingham

Research output: Contribution to journalArticle

474 Scopus citations

Abstract

MyoDl and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoDl and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants cultured in vitro, indicates that they may have different functions in different types of muscle during development.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalNature
Volume341
Issue number6240
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

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    Sassoon, D., Lyons, G., Wright, W. E., Lin, V., Lassar, A., Weintraub, H., & Buckingham, M. (1989). Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis. Nature, 341(6240), 303-307. https://doi.org/10.1038/341303a0