Extended high-frequency partial liquid ventilation in lung injury: Gas exchange, injury quantification, and vapor loss

Allan Doctor, Eman Al-Khadra, Puay Tan, Kenneth F. Watson, Diana L. Diesen, Lisa J. Workman, John E. Thompson, Charles E. Rose, John H. Arnold

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

High-frequency oscillatory ventilation with perflubron (PFB) reportedly improves pulmonary mechanics and gas exchange and attenuates lung injury. We explored PFB evaporative loss kinetics, intrapulmonary PFB distribution, and dosing strategies during 15 h of high-frequency oscillation (HFO)-partial liquid ventilation (PLV). After saline lavage lung injury, 15 swine were rescued with high-frequency oscillatory ventilation (n = 5), or in addition received 10 ml/kg PFB delivered to dependent lung [n = 5, PLV-compartmented (PLV(C))] or 10 ml/kg distributed uniformly within the lung [n = 5, PLV(U)]. In the PLV(C) group, PFB vapor loss was replaced. ANOVA revealed an unsustained improvement in oxygenation index in the PLV(U) group (P = 0.04); the reduction in oxygenation index correlated with PFB losses. Although tissue myeloperoxidase activity was reduced globally by HFO-PLV (P < 0.01) and regional lung injury scores (lung injury scores) in dependent lung were improved (P = 0.05), global lung injury scores were improved by HFO-PLV (P < 0.05) only in atelectasis, edema, and alveolar distension but not in cumulative score. In our model, markers of inflammation and lung injury were attenuated by HFO-PLV, and it appears that uniform intrapulmonary PFB distribution optimized gas exchange during HFO-PLV; additionally, monitoring PFB evaporative loss appears necessary to stabilize intrapulmonary PFB volume.

Original languageEnglish (US)
Pages (from-to)1248-1258
Number of pages11
JournalJournal of Applied Physiology
Volume95
Issue number3
StatePublished - Sep 1 2003

Fingerprint

Liquid Ventilation
Lung Injury
Gases
Wounds and Injuries
High-Frequency Ventilation
Lung
Pulmonary Gas Exchange
perflubron
Pulmonary Atelectasis
Therapeutic Irrigation
Mechanics
Peroxidase
Edema
Analysis of Variance
Swine

Keywords

  • Acute respiratory distress syndrome
  • High-frequency oscillatory ventilation
  • Myeloperoxidase activity
  • Perflubron
  • Perfluorochemical

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Doctor, A., Al-Khadra, E., Tan, P., Watson, K. F., Diesen, D. L., Workman, L. J., ... Arnold, J. H. (2003). Extended high-frequency partial liquid ventilation in lung injury: Gas exchange, injury quantification, and vapor loss. Journal of Applied Physiology, 95(3), 1248-1258.

Extended high-frequency partial liquid ventilation in lung injury : Gas exchange, injury quantification, and vapor loss. / Doctor, Allan; Al-Khadra, Eman; Tan, Puay; Watson, Kenneth F.; Diesen, Diana L.; Workman, Lisa J.; Thompson, John E.; Rose, Charles E.; Arnold, John H.

In: Journal of Applied Physiology, Vol. 95, No. 3, 01.09.2003, p. 1248-1258.

Research output: Contribution to journalArticle

Doctor, A, Al-Khadra, E, Tan, P, Watson, KF, Diesen, DL, Workman, LJ, Thompson, JE, Rose, CE & Arnold, JH 2003, 'Extended high-frequency partial liquid ventilation in lung injury: Gas exchange, injury quantification, and vapor loss', Journal of Applied Physiology, vol. 95, no. 3, pp. 1248-1258.
Doctor, Allan ; Al-Khadra, Eman ; Tan, Puay ; Watson, Kenneth F. ; Diesen, Diana L. ; Workman, Lisa J. ; Thompson, John E. ; Rose, Charles E. ; Arnold, John H. / Extended high-frequency partial liquid ventilation in lung injury : Gas exchange, injury quantification, and vapor loss. In: Journal of Applied Physiology. 2003 ; Vol. 95, No. 3. pp. 1248-1258.
@article{56354b2be23042388b0e59099217657d,
title = "Extended high-frequency partial liquid ventilation in lung injury: Gas exchange, injury quantification, and vapor loss",
abstract = "High-frequency oscillatory ventilation with perflubron (PFB) reportedly improves pulmonary mechanics and gas exchange and attenuates lung injury. We explored PFB evaporative loss kinetics, intrapulmonary PFB distribution, and dosing strategies during 15 h of high-frequency oscillation (HFO)-partial liquid ventilation (PLV). After saline lavage lung injury, 15 swine were rescued with high-frequency oscillatory ventilation (n = 5), or in addition received 10 ml/kg PFB delivered to dependent lung [n = 5, PLV-compartmented (PLV(C))] or 10 ml/kg distributed uniformly within the lung [n = 5, PLV(U)]. In the PLV(C) group, PFB vapor loss was replaced. ANOVA revealed an unsustained improvement in oxygenation index in the PLV(U) group (P = 0.04); the reduction in oxygenation index correlated with PFB losses. Although tissue myeloperoxidase activity was reduced globally by HFO-PLV (P < 0.01) and regional lung injury scores (lung injury scores) in dependent lung were improved (P = 0.05), global lung injury scores were improved by HFO-PLV (P < 0.05) only in atelectasis, edema, and alveolar distension but not in cumulative score. In our model, markers of inflammation and lung injury were attenuated by HFO-PLV, and it appears that uniform intrapulmonary PFB distribution optimized gas exchange during HFO-PLV; additionally, monitoring PFB evaporative loss appears necessary to stabilize intrapulmonary PFB volume.",
keywords = "Acute respiratory distress syndrome, High-frequency oscillatory ventilation, Myeloperoxidase activity, Perflubron, Perfluorochemical",
author = "Allan Doctor and Eman Al-Khadra and Puay Tan and Watson, {Kenneth F.} and Diesen, {Diana L.} and Workman, {Lisa J.} and Thompson, {John E.} and Rose, {Charles E.} and Arnold, {John H.}",
year = "2003",
month = "9",
day = "1",
language = "English (US)",
volume = "95",
pages = "1248--1258",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Extended high-frequency partial liquid ventilation in lung injury

T2 - Gas exchange, injury quantification, and vapor loss

AU - Doctor, Allan

AU - Al-Khadra, Eman

AU - Tan, Puay

AU - Watson, Kenneth F.

AU - Diesen, Diana L.

AU - Workman, Lisa J.

AU - Thompson, John E.

AU - Rose, Charles E.

AU - Arnold, John H.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - High-frequency oscillatory ventilation with perflubron (PFB) reportedly improves pulmonary mechanics and gas exchange and attenuates lung injury. We explored PFB evaporative loss kinetics, intrapulmonary PFB distribution, and dosing strategies during 15 h of high-frequency oscillation (HFO)-partial liquid ventilation (PLV). After saline lavage lung injury, 15 swine were rescued with high-frequency oscillatory ventilation (n = 5), or in addition received 10 ml/kg PFB delivered to dependent lung [n = 5, PLV-compartmented (PLV(C))] or 10 ml/kg distributed uniformly within the lung [n = 5, PLV(U)]. In the PLV(C) group, PFB vapor loss was replaced. ANOVA revealed an unsustained improvement in oxygenation index in the PLV(U) group (P = 0.04); the reduction in oxygenation index correlated with PFB losses. Although tissue myeloperoxidase activity was reduced globally by HFO-PLV (P < 0.01) and regional lung injury scores (lung injury scores) in dependent lung were improved (P = 0.05), global lung injury scores were improved by HFO-PLV (P < 0.05) only in atelectasis, edema, and alveolar distension but not in cumulative score. In our model, markers of inflammation and lung injury were attenuated by HFO-PLV, and it appears that uniform intrapulmonary PFB distribution optimized gas exchange during HFO-PLV; additionally, monitoring PFB evaporative loss appears necessary to stabilize intrapulmonary PFB volume.

AB - High-frequency oscillatory ventilation with perflubron (PFB) reportedly improves pulmonary mechanics and gas exchange and attenuates lung injury. We explored PFB evaporative loss kinetics, intrapulmonary PFB distribution, and dosing strategies during 15 h of high-frequency oscillation (HFO)-partial liquid ventilation (PLV). After saline lavage lung injury, 15 swine were rescued with high-frequency oscillatory ventilation (n = 5), or in addition received 10 ml/kg PFB delivered to dependent lung [n = 5, PLV-compartmented (PLV(C))] or 10 ml/kg distributed uniformly within the lung [n = 5, PLV(U)]. In the PLV(C) group, PFB vapor loss was replaced. ANOVA revealed an unsustained improvement in oxygenation index in the PLV(U) group (P = 0.04); the reduction in oxygenation index correlated with PFB losses. Although tissue myeloperoxidase activity was reduced globally by HFO-PLV (P < 0.01) and regional lung injury scores (lung injury scores) in dependent lung were improved (P = 0.05), global lung injury scores were improved by HFO-PLV (P < 0.05) only in atelectasis, edema, and alveolar distension but not in cumulative score. In our model, markers of inflammation and lung injury were attenuated by HFO-PLV, and it appears that uniform intrapulmonary PFB distribution optimized gas exchange during HFO-PLV; additionally, monitoring PFB evaporative loss appears necessary to stabilize intrapulmonary PFB volume.

KW - Acute respiratory distress syndrome

KW - High-frequency oscillatory ventilation

KW - Myeloperoxidase activity

KW - Perflubron

KW - Perfluorochemical

UR - http://www.scopus.com/inward/record.url?scp=0042924166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042924166&partnerID=8YFLogxK

M3 - Article

C2 - 12754177

AN - SCOPUS:0042924166

VL - 95

SP - 1248

EP - 1258

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 3

ER -