Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia

Anne L. Solevåg, Ingrid Dannevig, Myra Wyckoff, Ola D. Saugstad, Britt Nakstad

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: The rationale for a compression to ventilation ratio of 3:1 in neonates with primary hypoxic, hypercapnic cardiac arrest is to emphasize the importance of ventilation; however, there are no published studies testing this approach against alternative methods. An extended series of cardiac compressions offers the theoretical advantage of improving coronary perfusion pressures and hence, we aimed to explore the impact of compression cycles of two different durations. Materials and methods: Newborn swine (n=32, age 12-36h, weight 2.0-2.7kg) were progressively asphyxiated until asystole occurred. Animals were randomized to receive compressions:ventilations 3:1 (n=16) or 9:3 (n=16). Return of spontaneous circulation (ROSC) was defined as a heart rate ≥100beatsmin-1. Results: All animals except one in the 9:3 group achieved ROSC. One animal in the 3:1 group suffered bradycardia at baseline, and was excluded, leaving us with 15 animals in each group surviving to completion of protocol. Time to ROSC (median and interquartile range) was 150 s (115-180) vs. 148 s (116-195) for 3:1 and 9:3, respectively (P= 0.74). There were no differences in diastolic blood pressure during compression cycles or in markers of hypoxia and inflammation. The temporal changes in mean arterial blood pressure, heart rate, arterial blood gas parameters, and systemic and regional oxygen saturation were comparable between groups. Conclusion: Neonatal pigs with asphyxia-induced cardiac arrest did not respond to a compression:ventilation ratio of 9:3 better than to 3:1. Future research should address if alternative compression:ventilation ratios offer advantages over the current gold standard of 3:1.

Original languageEnglish (US)
Pages (from-to)1571-1576
Number of pages6
JournalResuscitation
Volume81
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Asphyxia
Cardiopulmonary Resuscitation
Ventilation
Swine
Heart Arrest
Arterial Pressure
Heart Rate
Blood Pressure
Induced Heart Arrest
Bradycardia
Perfusion
Gases
Oxygen
Inflammation
Pressure
Weights and Measures

Keywords

  • Asphyxia
  • Asystole
  • Cardiopulmonary resuscitation (CPR)
  • Chest compression
  • Coronary perfusion pressure
  • Neonatal resuscitation
  • Return of spontaneous circulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine

Cite this

Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia. / Solevåg, Anne L.; Dannevig, Ingrid; Wyckoff, Myra; Saugstad, Ola D.; Nakstad, Britt.

In: Resuscitation, Vol. 81, No. 11, 11.2010, p. 1571-1576.

Research output: Contribution to journalArticle

Solevåg, Anne L. ; Dannevig, Ingrid ; Wyckoff, Myra ; Saugstad, Ola D. ; Nakstad, Britt. / Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia. In: Resuscitation. 2010 ; Vol. 81, No. 11. pp. 1571-1576.
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