External scintigraphy in monitoring the behavior of pharmaceutical formulations in vivo. I: technique for acquiring high-resolution images of tablets

M. C. Theodorakis, D. R. Simpson, D. M. Leung, M. Devous

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A new method for monotoring tablet disintegration in vivo was developed. In this method, the tablets were labeled with a short-lived radionuclide, technetium 99m, and monitored by a gamma camera. Several innovations were introduced with this method. First, computer reconstruction algorithms were used to enhance the scintigraphic images of the disintegrating tablet in vivo. Second, the use of a four-pinhole collimator to acquire multiple views of the tablet resulted in high count rates and reduced acquisition times of the scintigraphic images. Third, the magnification of the scintigraphic images achieved by pinhole collimation led to significant improvement in resolution. Fourth, the radioinuclide was incorporated into the granulation so that the whole mass of the tablet was uniformly labeled with high levels of activity. This technique allowed the continuous monotoring of the disintegration process of tablets in vivo in experimental animals. Multiple pinhole collimation and the labeling process permitted the acquisition of quality scintigraphic images of the labeled tablet every 30 sec. The resolution of the method was tested in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalJournal of Pharmaceutical Sciences
Volume72
Issue number2
StatePublished - 1983

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Drug Compounding
Image resolution
Radionuclide Imaging
Tablets
Monitoring
Pharmaceutical Preparations
Disintegration
Gamma Cameras
Granulation
Technetium
Radioisotopes
Labeling
Image quality
Animals
Innovation
Cameras

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

External scintigraphy in monitoring the behavior of pharmaceutical formulations in vivo. I : technique for acquiring high-resolution images of tablets. / Theodorakis, M. C.; Simpson, D. R.; Leung, D. M.; Devous, M.

In: Journal of Pharmaceutical Sciences, Vol. 72, No. 2, 1983, p. 130-135.

Research output: Contribution to journalArticle

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