Extra-thymic immature T cells: Development in polyoma virus-induced murine salivary gland tumors

G. P. Hoot, J. R. Kettman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lymphocyte infiltrates which occur in some polyoma virus-induced murine salivary epithelial tumors are characterized. The lymphocytic infiltrates within the salivary tumors resemble cortical thymocytes with the phenotype PNA+ Thy-1.2(bright), Ly-2+L3T4+, Ly-1(dim), KJ16-133-. The salivary lymphocytes showed proliferation based on analysis of RNA and DNA content. Because thymocytes lose the immature phenotype before leaving the thymus, we propose that the salivary tumor infiltrates result from the intra-tumoral differentiation of blood-derived prothymocytes into 'cortical thymocytes'. Histologic examination of the salivary tumors indicates expression of class II major histocompatibility antigen on the tumor epithelium which may be essential in establishing the extra-thymic T lymphocyte-inductive microenvironment within the tumor.

Original languageEnglish (US)
Pages (from-to)1991-1998
Number of pages8
JournalEuropean Journal of Immunology
Volume19
Issue number11
DOIs
StatePublished - 1989

Fingerprint

Polyomavirus
Glandular and Epithelial Neoplasms
T-Lymphocytes
Thymocytes
Neoplasms
Lymphocytes
Phenotype
Tumor Microenvironment
Histocompatibility Antigens Class II
Thymus Gland
Epithelium
RNA
DNA

ASJC Scopus subject areas

  • Immunology

Cite this

Extra-thymic immature T cells : Development in polyoma virus-induced murine salivary gland tumors. / Hoot, G. P.; Kettman, J. R.

In: European Journal of Immunology, Vol. 19, No. 11, 1989, p. 1991-1998.

Research output: Contribution to journalArticle

@article{5ca5ccfe93f74e8c813951016cc46e6e,
title = "Extra-thymic immature T cells: Development in polyoma virus-induced murine salivary gland tumors",
abstract = "Lymphocyte infiltrates which occur in some polyoma virus-induced murine salivary epithelial tumors are characterized. The lymphocytic infiltrates within the salivary tumors resemble cortical thymocytes with the phenotype PNA+ Thy-1.2(bright), Ly-2+L3T4+, Ly-1(dim), KJ16-133-. The salivary lymphocytes showed proliferation based on analysis of RNA and DNA content. Because thymocytes lose the immature phenotype before leaving the thymus, we propose that the salivary tumor infiltrates result from the intra-tumoral differentiation of blood-derived prothymocytes into 'cortical thymocytes'. Histologic examination of the salivary tumors indicates expression of class II major histocompatibility antigen on the tumor epithelium which may be essential in establishing the extra-thymic T lymphocyte-inductive microenvironment within the tumor.",
author = "Hoot, {G. P.} and Kettman, {J. R.}",
year = "1989",
doi = "10.1002/eji.1830191104",
language = "English (US)",
volume = "19",
pages = "1991--1998",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "11",

}

TY - JOUR

T1 - Extra-thymic immature T cells

T2 - Development in polyoma virus-induced murine salivary gland tumors

AU - Hoot, G. P.

AU - Kettman, J. R.

PY - 1989

Y1 - 1989

N2 - Lymphocyte infiltrates which occur in some polyoma virus-induced murine salivary epithelial tumors are characterized. The lymphocytic infiltrates within the salivary tumors resemble cortical thymocytes with the phenotype PNA+ Thy-1.2(bright), Ly-2+L3T4+, Ly-1(dim), KJ16-133-. The salivary lymphocytes showed proliferation based on analysis of RNA and DNA content. Because thymocytes lose the immature phenotype before leaving the thymus, we propose that the salivary tumor infiltrates result from the intra-tumoral differentiation of blood-derived prothymocytes into 'cortical thymocytes'. Histologic examination of the salivary tumors indicates expression of class II major histocompatibility antigen on the tumor epithelium which may be essential in establishing the extra-thymic T lymphocyte-inductive microenvironment within the tumor.

AB - Lymphocyte infiltrates which occur in some polyoma virus-induced murine salivary epithelial tumors are characterized. The lymphocytic infiltrates within the salivary tumors resemble cortical thymocytes with the phenotype PNA+ Thy-1.2(bright), Ly-2+L3T4+, Ly-1(dim), KJ16-133-. The salivary lymphocytes showed proliferation based on analysis of RNA and DNA content. Because thymocytes lose the immature phenotype before leaving the thymus, we propose that the salivary tumor infiltrates result from the intra-tumoral differentiation of blood-derived prothymocytes into 'cortical thymocytes'. Histologic examination of the salivary tumors indicates expression of class II major histocompatibility antigen on the tumor epithelium which may be essential in establishing the extra-thymic T lymphocyte-inductive microenvironment within the tumor.

UR - http://www.scopus.com/inward/record.url?scp=0024819222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024819222&partnerID=8YFLogxK

U2 - 10.1002/eji.1830191104

DO - 10.1002/eji.1830191104

M3 - Article

C2 - 2574678

AN - SCOPUS:0024819222

VL - 19

SP - 1991

EP - 1998

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 11

ER -