Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement

Matteo Di Nardo, Ali H. Ahmad, Pietro Merli, Matthew S. Zinter, Leslie E. Lehman, Courtney M. Rowan, Marie E. Steiner, Sangeeta Hingorani, Joseph R. Angelo, Hisham Abdel-Azim, Sajad J. Khazal, Basirat Shoberu, Jennifer McArthur, Rajinder Bajwa, Saad Ghafoor, Samir H. Shah, Hitesh Sandhu, Karen Moody, Brandon D. Brown, Maria E. MirelesDiana Steppan, Taylor Olson, Lakshmi Raman, Brian Bridges, Christine N. Duncan, Sung Won Choi, Rita Swinford, Matt Paden, James D. Fortenberry, Giles Peek, Pierre Tissieres, Daniele De Luca, Franco Locatelli, Selim Corbacioglu, Martin Kneyber, Alessio Franceschini, Simon Nadel, Matthias Kumpf, Alessandra Loreti, Roelie Wösten-Van Asperen, Orsola Gawronski, Joe Brierley, Graeme MacLaren, Kris M. Mahadeo

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Use of extracorporeal membrane oxygenation (ECMO) in children receiving haematopoietic cell transplantation (HCT) and immune effector cell therapy is controversial and evidence-based guidelines have not been established. Remarkable advancements in HCT and immune effector cell therapies have changed expectations around reversibility of organ dysfunction and survival for affected patients. Herein, members of the Extracorporeal Life Support Organization (ELSO), Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (HCT and cancer immunotherapy subgroup), the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT), the supportive care committee of the Pediatric Transplantation and Cellular Therapy Consortium (PTCTC), and the Pediatric Intensive Care Oncology Kids in Europe Research (POKER) group of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) provide consensus recommendations on the use of ECMO in children receiving HCT and immune effector cell therapy. These are the first international, multidisciplinary consensus-based recommendations on the use of ECMO in this patient population. This Review provides a clinical decision support tool for paediatric haematologists, oncologists, and critical care physicians during the difficult decision-making process of ECMO candidacy and management. These recommendations can represent a base for future research studies focused on ECMO selection criteria and bedside management.

Original languageEnglish (US)
Pages (from-to)116-128
Number of pages13
JournalThe Lancet Child and Adolescent Health
Volume6
Issue number2
DOIs
StatePublished - Feb 2022
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology

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