Extracranial radiosurgery (stereotactic body radiation therapy) for oligometastases

Brian D. Kavanagh, Ronald C. McGarry, Robert D. Timmerman

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Extracranial radiosurgery, also known as stereotactic body radiation therapy (SBRT), is an increasingly used method of treatment of limited cancer metastases located in a variety of organs/sites including the spine, lungs, liver, and other areas in the abdomen and pelvis. The techniques used to perform SBRT were initially modeled after intracranial radiosurgery, although considerable evolution in technique and conduct has occurred for extracranial applications. Unlike intracranial radiosurgery, SBRT requires characterization and accounting for inherent organ movement including breathing motion. Potent dose hypofractionation schedules have been used with SBRT such that the treatment is generally both ablative and convenient. Because the treatment is severely damaging to tissues within and about the target, the volume of adjacent normal tissue must be strictly minimized to avoid toxic late effects. Outcomes in various sites show very high rates of local control with toxicity mostly related to tubular tissues like the airways and bowels. With proper conduct though, SBRT can be an extremely effective treatment option for oligometastases.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalSeminars in Radiation Oncology
Volume16
Issue number2
DOIs
StatePublished - Apr 2006

Fingerprint

Radiosurgery
radiation therapy
Radiotherapy
organs
abdomen
pelvis
spine
Poisons
metastasis
Therapeutics
breathing
schedules
Pelvis
liver
toxicity
Abdomen
lungs
Appointments and Schedules
Respiration
Spine

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

Extracranial radiosurgery (stereotactic body radiation therapy) for oligometastases. / Kavanagh, Brian D.; McGarry, Ronald C.; Timmerman, Robert D.

In: Seminars in Radiation Oncology, Vol. 16, No. 2, 04.2006, p. 77-84.

Research output: Contribution to journalArticle

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