Extramedullary blast crisis in chronic myelogenous leukemia: Demonstration of T-cell lineage and Philadelphia chromosome in a paraspinal tumor

T. Sun, M. Susin, P. Koduru, E. L. Coffey, K. Dittmar, R. Weiss, J. Goh, J. Brody

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A case of chronic myelogenous leukemia (CML) with penetrance of the Ph1 molecular alteration into the T-cell lineage of a paraspinal tumor is reported. The T-cell nature of the paraspinal tumor was documented by immunochemical study and genotyping. The Philadelphia chromosome was also detected by genotyping in the same tumor cell population. To the authors' knowledge, this is the first case of extramedullary T-cell blast crisis in CML demonstrated in an extranodal tumor. The clinical significance of detecting extramedullary blast crisis, and the theories for the scarcity of T-cell transformation in CML are discussed.

Original languageEnglish (US)
Pages (from-to)605-610
Number of pages6
JournalCancer
Volume68
Issue number3
StatePublished - 1991

Fingerprint

Blast Crisis
Philadelphia Chromosome
Cell Lineage
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
T-Lymphocytes
Neoplasms
Penetrance
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Extramedullary blast crisis in chronic myelogenous leukemia : Demonstration of T-cell lineage and Philadelphia chromosome in a paraspinal tumor. / Sun, T.; Susin, M.; Koduru, P.; Coffey, E. L.; Dittmar, K.; Weiss, R.; Goh, J.; Brody, J.

In: Cancer, Vol. 68, No. 3, 1991, p. 605-610.

Research output: Contribution to journalArticle

Sun, T, Susin, M, Koduru, P, Coffey, EL, Dittmar, K, Weiss, R, Goh, J & Brody, J 1991, 'Extramedullary blast crisis in chronic myelogenous leukemia: Demonstration of T-cell lineage and Philadelphia chromosome in a paraspinal tumor', Cancer, vol. 68, no. 3, pp. 605-610.
Sun, T. ; Susin, M. ; Koduru, P. ; Coffey, E. L. ; Dittmar, K. ; Weiss, R. ; Goh, J. ; Brody, J. / Extramedullary blast crisis in chronic myelogenous leukemia : Demonstration of T-cell lineage and Philadelphia chromosome in a paraspinal tumor. In: Cancer. 1991 ; Vol. 68, No. 3. pp. 605-610.
@article{3ed0d737050c4adc8d548f4155b1b54a,
title = "Extramedullary blast crisis in chronic myelogenous leukemia: Demonstration of T-cell lineage and Philadelphia chromosome in a paraspinal tumor",
abstract = "A case of chronic myelogenous leukemia (CML) with penetrance of the Ph1 molecular alteration into the T-cell lineage of a paraspinal tumor is reported. The T-cell nature of the paraspinal tumor was documented by immunochemical study and genotyping. The Philadelphia chromosome was also detected by genotyping in the same tumor cell population. To the authors' knowledge, this is the first case of extramedullary T-cell blast crisis in CML demonstrated in an extranodal tumor. The clinical significance of detecting extramedullary blast crisis, and the theories for the scarcity of T-cell transformation in CML are discussed.",
author = "T. Sun and M. Susin and P. Koduru and Coffey, {E. L.} and K. Dittmar and R. Weiss and J. Goh and J. Brody",
year = "1991",
language = "English (US)",
volume = "68",
pages = "605--610",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Extramedullary blast crisis in chronic myelogenous leukemia

T2 - Demonstration of T-cell lineage and Philadelphia chromosome in a paraspinal tumor

AU - Sun, T.

AU - Susin, M.

AU - Koduru, P.

AU - Coffey, E. L.

AU - Dittmar, K.

AU - Weiss, R.

AU - Goh, J.

AU - Brody, J.

PY - 1991

Y1 - 1991

N2 - A case of chronic myelogenous leukemia (CML) with penetrance of the Ph1 molecular alteration into the T-cell lineage of a paraspinal tumor is reported. The T-cell nature of the paraspinal tumor was documented by immunochemical study and genotyping. The Philadelphia chromosome was also detected by genotyping in the same tumor cell population. To the authors' knowledge, this is the first case of extramedullary T-cell blast crisis in CML demonstrated in an extranodal tumor. The clinical significance of detecting extramedullary blast crisis, and the theories for the scarcity of T-cell transformation in CML are discussed.

AB - A case of chronic myelogenous leukemia (CML) with penetrance of the Ph1 molecular alteration into the T-cell lineage of a paraspinal tumor is reported. The T-cell nature of the paraspinal tumor was documented by immunochemical study and genotyping. The Philadelphia chromosome was also detected by genotyping in the same tumor cell population. To the authors' knowledge, this is the first case of extramedullary T-cell blast crisis in CML demonstrated in an extranodal tumor. The clinical significance of detecting extramedullary blast crisis, and the theories for the scarcity of T-cell transformation in CML are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0026094267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026094267&partnerID=8YFLogxK

M3 - Article

C2 - 2065281

AN - SCOPUS:0026094267

VL - 68

SP - 605

EP - 610

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 3

ER -