Extranodal Non-Hodgkin's lymphomas - A retrospective review of clinico-pathologic features and outcomes in comparison with nodal Non-Hodgkin's lymphomas

Amar Lal, Yasmin Bhurgri, Irfan Vaziri, Nida B. Rizvi, Aliyah Sadaf, Saba Sartajuddin, Mohammed Islam, Pawan Kumar, Salman Adil, Ghulam Nabi Kakepoto, Nehal Masood, Mohammed Khurshed, Amyn Alidina

Research output: Contribution to journalArticle

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Abstract

Objective: The primary objective of this study was to analyze the anatomic distribution, clinical features and outcome of Diffuse large B-cell lymphoma (DLBCL) patients according to the primary site (extranodal vs. nodal) with applicability of International Prognostic Index (IPI). Methodology: A retrospective review (1988 to 2004) of 557 cases of DLBC. Results: The median age was 48.7 ± 15.3 years; M:F ratio was 2:1. The distribution according to the primary site was: lymph node (N-NHL), 322 cases (58%) of which 145(44%) were stage IV, 76 (23%) stage III, 60 (18%) stage II and 47 (15%) stage I. The extra nodal sites (EN-NHL) 235 (42%) cases included gastro-intestinal tract (44%), upper aerodigestive tract (19%), bones (8%), spine (5%), and unusual sites less than 3% each as breast, CNS, testis, lungs and skin. The median survival rate was 4.8 years and 6.3 years in N-NHL and EN-NHL respectively. In the latter this varied greatly depending on the primary site and stage of disease at presentation. In the univariate analysis factors associated with good prognosis were: age less than 60 years, early stage (I-II), extranodal involvement primarily gastric or bone, 0-1 extranodal site, 0-1 performance status, lack of B symptoms and normal LDH level. In the multivariate analysis age, performance status, stage of disease and level of LDH were the main variables predicting overall survival; no nodal or extranodal site maintained their prognostic value. Conclusion: Patients with EN-NHL present more frequently with early stage disease then those with N-NHL; overall survival in both groups largely depended on IPI and not on the site of origin of the malignancy.

Original languageEnglish (US)
Pages (from-to)453-458
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume9
Issue number3
StatePublished - Jan 1 2008

Fingerprint

Non-Hodgkin's Lymphoma
Hospital Distribution Systems
Bone and Bones
Survival
Lymphoma, Large B-Cell, Diffuse
Statistical Factor Analysis
Testis
Stomach
Breast
Spine
Multivariate Analysis
Survival Rate
Lymph Nodes
Lung
Skin
Neoplasms

Keywords

  • Extranodal NHL
  • Karachi
  • Nodal NHL
  • Non-Hodgkin's Lymphoma (NHL)
  • Pakistan

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Extranodal Non-Hodgkin's lymphomas - A retrospective review of clinico-pathologic features and outcomes in comparison with nodal Non-Hodgkin's lymphomas. / Lal, Amar; Bhurgri, Yasmin; Vaziri, Irfan; Rizvi, Nida B.; Sadaf, Aliyah; Sartajuddin, Saba; Islam, Mohammed; Kumar, Pawan; Adil, Salman; Kakepoto, Ghulam Nabi; Masood, Nehal; Khurshed, Mohammed; Alidina, Amyn.

In: Asian Pacific Journal of Cancer Prevention, Vol. 9, No. 3, 01.01.2008, p. 453-458.

Research output: Contribution to journalArticle

Lal, A, Bhurgri, Y, Vaziri, I, Rizvi, NB, Sadaf, A, Sartajuddin, S, Islam, M, Kumar, P, Adil, S, Kakepoto, GN, Masood, N, Khurshed, M & Alidina, A 2008, 'Extranodal Non-Hodgkin's lymphomas - A retrospective review of clinico-pathologic features and outcomes in comparison with nodal Non-Hodgkin's lymphomas', Asian Pacific Journal of Cancer Prevention, vol. 9, no. 3, pp. 453-458.
Lal, Amar ; Bhurgri, Yasmin ; Vaziri, Irfan ; Rizvi, Nida B. ; Sadaf, Aliyah ; Sartajuddin, Saba ; Islam, Mohammed ; Kumar, Pawan ; Adil, Salman ; Kakepoto, Ghulam Nabi ; Masood, Nehal ; Khurshed, Mohammed ; Alidina, Amyn. / Extranodal Non-Hodgkin's lymphomas - A retrospective review of clinico-pathologic features and outcomes in comparison with nodal Non-Hodgkin's lymphomas. In: Asian Pacific Journal of Cancer Prevention. 2008 ; Vol. 9, No. 3. pp. 453-458.
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abstract = "Objective: The primary objective of this study was to analyze the anatomic distribution, clinical features and outcome of Diffuse large B-cell lymphoma (DLBCL) patients according to the primary site (extranodal vs. nodal) with applicability of International Prognostic Index (IPI). Methodology: A retrospective review (1988 to 2004) of 557 cases of DLBC. Results: The median age was 48.7 ± 15.3 years; M:F ratio was 2:1. The distribution according to the primary site was: lymph node (N-NHL), 322 cases (58{\%}) of which 145(44{\%}) were stage IV, 76 (23{\%}) stage III, 60 (18{\%}) stage II and 47 (15{\%}) stage I. The extra nodal sites (EN-NHL) 235 (42{\%}) cases included gastro-intestinal tract (44{\%}), upper aerodigestive tract (19{\%}), bones (8{\%}), spine (5{\%}), and unusual sites less than 3{\%} each as breast, CNS, testis, lungs and skin. The median survival rate was 4.8 years and 6.3 years in N-NHL and EN-NHL respectively. In the latter this varied greatly depending on the primary site and stage of disease at presentation. In the univariate analysis factors associated with good prognosis were: age less than 60 years, early stage (I-II), extranodal involvement primarily gastric or bone, 0-1 extranodal site, 0-1 performance status, lack of B symptoms and normal LDH level. In the multivariate analysis age, performance status, stage of disease and level of LDH were the main variables predicting overall survival; no nodal or extranodal site maintained their prognostic value. Conclusion: Patients with EN-NHL present more frequently with early stage disease then those with N-NHL; overall survival in both groups largely depended on IPI and not on the site of origin of the malignancy.",
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AU - Lal, Amar

AU - Bhurgri, Yasmin

AU - Vaziri, Irfan

AU - Rizvi, Nida B.

AU - Sadaf, Aliyah

AU - Sartajuddin, Saba

AU - Islam, Mohammed

AU - Kumar, Pawan

AU - Adil, Salman

AU - Kakepoto, Ghulam Nabi

AU - Masood, Nehal

AU - Khurshed, Mohammed

AU - Alidina, Amyn

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N2 - Objective: The primary objective of this study was to analyze the anatomic distribution, clinical features and outcome of Diffuse large B-cell lymphoma (DLBCL) patients according to the primary site (extranodal vs. nodal) with applicability of International Prognostic Index (IPI). Methodology: A retrospective review (1988 to 2004) of 557 cases of DLBC. Results: The median age was 48.7 ± 15.3 years; M:F ratio was 2:1. The distribution according to the primary site was: lymph node (N-NHL), 322 cases (58%) of which 145(44%) were stage IV, 76 (23%) stage III, 60 (18%) stage II and 47 (15%) stage I. The extra nodal sites (EN-NHL) 235 (42%) cases included gastro-intestinal tract (44%), upper aerodigestive tract (19%), bones (8%), spine (5%), and unusual sites less than 3% each as breast, CNS, testis, lungs and skin. The median survival rate was 4.8 years and 6.3 years in N-NHL and EN-NHL respectively. In the latter this varied greatly depending on the primary site and stage of disease at presentation. In the univariate analysis factors associated with good prognosis were: age less than 60 years, early stage (I-II), extranodal involvement primarily gastric or bone, 0-1 extranodal site, 0-1 performance status, lack of B symptoms and normal LDH level. In the multivariate analysis age, performance status, stage of disease and level of LDH were the main variables predicting overall survival; no nodal or extranodal site maintained their prognostic value. Conclusion: Patients with EN-NHL present more frequently with early stage disease then those with N-NHL; overall survival in both groups largely depended on IPI and not on the site of origin of the malignancy.

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KW - Non-Hodgkin's Lymphoma (NHL)

KW - Pakistan

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