Extubation Failure and Tracheostomy Placement in Children with Acute Neurocritical Illness

Ellen C. Cohn, Tammy S. Robertson, Stacey A. Scott, Andre M. Finley, Rong Huang, Darryl K. Miles

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: There is a lack of data describing the risk factors for extubation failure (EF) or tracheostomy placement in pediatric neurocritical care (NCC) patients. Methods: A retrospective chart review of children admitted to the pediatric intensive care unit who were intubated for >24 h with an acute neurocritical illness and had an extubation attempt. Bivariate and multivariate statistical analysis was performed to determine significant associations of demographic, neurologic, pulmonary, and clinical variables with EF and tracheostomy placement. Analysis of predictive factors for EF (within 48 h) and tracheostomy placement during the hospitalization was conducted on a first extubation attempt group (n = 193) and a second attempt group (n = 23) who experienced either EF or a “late re-intubation” (>48 h–7 days). Results: Traumatic brain injury (37.3%) and seizures/status epilepticus (31.4%) were the most common diagnoses with neuromuscular weakness patients having the highest risk for EF and tracheostomy placement. EF occurred in 20/193 (10.4%) patients after their first attempt and 6/23 (26.1%) after a second attempt. Compared to those with a fair/strong cough, patients with a weak/absent cough had a relative risk (RR) of 9.4 for EF (95% CI, 4.9–17.9, p < 0.001) and 6.7 (95% CI, 2.3–18.9, p = 0.01) for tracheostomy placement on the first and second attempts, respectively. Glasgow Coma Score (GCS), endotracheal tube (ETT) secretion characteristics, and pulmonary variables were not associated with EF or tracheostomy placement. Conclusions: A weak/absent cough reflex is associated with an increased risk of failing extubation and placement of a tracheostomy in intubated pediatric NCC patients.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalNeurocritical Care
DOIs
StateAccepted/In press - Jul 25 2017

Fingerprint

Tracheostomy
Cough
Patient Care
Pediatrics
Abnormal Reflexes
Lung
Pediatric Intensive Care Units
Status Epilepticus
Coma
Intubation
Nervous System
Statistical Factor Analysis
Seizures
Hospitalization
Multivariate Analysis
Demography

Keywords

  • Airway extubation
  • Brain injuries
  • Child
  • Neurologic disorders
  • Pediatric intensive care units
  • Respiration, artificial
  • Risk factors
  • Tracheostomy

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Clinical Neurology

Cite this

Extubation Failure and Tracheostomy Placement in Children with Acute Neurocritical Illness. / Cohn, Ellen C.; Robertson, Tammy S.; Scott, Stacey A.; Finley, Andre M.; Huang, Rong; Miles, Darryl K.

In: Neurocritical Care, 25.07.2017, p. 1-10.

Research output: Contribution to journalArticle

Cohn, Ellen C. ; Robertson, Tammy S. ; Scott, Stacey A. ; Finley, Andre M. ; Huang, Rong ; Miles, Darryl K. / Extubation Failure and Tracheostomy Placement in Children with Acute Neurocritical Illness. In: Neurocritical Care. 2017 ; pp. 1-10.
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abstract = "Background: There is a lack of data describing the risk factors for extubation failure (EF) or tracheostomy placement in pediatric neurocritical care (NCC) patients. Methods: A retrospective chart review of children admitted to the pediatric intensive care unit who were intubated for >24 h with an acute neurocritical illness and had an extubation attempt. Bivariate and multivariate statistical analysis was performed to determine significant associations of demographic, neurologic, pulmonary, and clinical variables with EF and tracheostomy placement. Analysis of predictive factors for EF (within 48 h) and tracheostomy placement during the hospitalization was conducted on a first extubation attempt group (n = 193) and a second attempt group (n = 23) who experienced either EF or a “late re-intubation” (>48 h–7 days). Results: Traumatic brain injury (37.3{\%}) and seizures/status epilepticus (31.4{\%}) were the most common diagnoses with neuromuscular weakness patients having the highest risk for EF and tracheostomy placement. EF occurred in 20/193 (10.4{\%}) patients after their first attempt and 6/23 (26.1{\%}) after a second attempt. Compared to those with a fair/strong cough, patients with a weak/absent cough had a relative risk (RR) of 9.4 for EF (95{\%} CI, 4.9–17.9, p < 0.001) and 6.7 (95{\%} CI, 2.3–18.9, p = 0.01) for tracheostomy placement on the first and second attempts, respectively. Glasgow Coma Score (GCS), endotracheal tube (ETT) secretion characteristics, and pulmonary variables were not associated with EF or tracheostomy placement. Conclusions: A weak/absent cough reflex is associated with an increased risk of failing extubation and placement of a tracheostomy in intubated pediatric NCC patients.",
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AU - Cohn, Ellen C.

AU - Robertson, Tammy S.

AU - Scott, Stacey A.

AU - Finley, Andre M.

AU - Huang, Rong

AU - Miles, Darryl K.

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AB - Background: There is a lack of data describing the risk factors for extubation failure (EF) or tracheostomy placement in pediatric neurocritical care (NCC) patients. Methods: A retrospective chart review of children admitted to the pediatric intensive care unit who were intubated for >24 h with an acute neurocritical illness and had an extubation attempt. Bivariate and multivariate statistical analysis was performed to determine significant associations of demographic, neurologic, pulmonary, and clinical variables with EF and tracheostomy placement. Analysis of predictive factors for EF (within 48 h) and tracheostomy placement during the hospitalization was conducted on a first extubation attempt group (n = 193) and a second attempt group (n = 23) who experienced either EF or a “late re-intubation” (>48 h–7 days). Results: Traumatic brain injury (37.3%) and seizures/status epilepticus (31.4%) were the most common diagnoses with neuromuscular weakness patients having the highest risk for EF and tracheostomy placement. EF occurred in 20/193 (10.4%) patients after their first attempt and 6/23 (26.1%) after a second attempt. Compared to those with a fair/strong cough, patients with a weak/absent cough had a relative risk (RR) of 9.4 for EF (95% CI, 4.9–17.9, p < 0.001) and 6.7 (95% CI, 2.3–18.9, p = 0.01) for tracheostomy placement on the first and second attempts, respectively. Glasgow Coma Score (GCS), endotracheal tube (ETT) secretion characteristics, and pulmonary variables were not associated with EF or tracheostomy placement. Conclusions: A weak/absent cough reflex is associated with an increased risk of failing extubation and placement of a tracheostomy in intubated pediatric NCC patients.

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KW - Neurologic disorders

KW - Pediatric intensive care units

KW - Respiration, artificial

KW - Risk factors

KW - Tracheostomy

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