Eye gaze and pupillary response in Angelman syndrome

Michael P. Hong, Janna L. Guilfoyle, Lindsey N. Mooney, Logan K. Wink, Ernest V. Pedapati, Rebecca C. Shaffer, John A. Sweeney, Craig A. Erickson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Angelman syndrome (AS) is a rare neurological disorder characterized by severe developmental disability, communication impairment, elevated seizure risk, and motor system abnormalities. Aims The aims of this study were to determine the feasibility of social scene eye tracking and pupillometry measures in individuals with AS and to compare the performance of AS participants to individuals with idiopathic Autism Spectrum Disorder (ASD) and typically developing controls (TDC). Methods and procedures Individuals with AS and age- and gender- matched controls completed a social eye tracking paradigm. Neurobehavioral characterization of AS participants was completed via a battery of psychological testing and caregiver behavioral evaluations. Outcomes and results Eight of seventeen recruited AS participants completed the eye tracking paradigm. Compared to TDC, AS subjects demonstrated significantly less preference for social scenes than geometric shapes. Additionally, AS subjects showed less pupil dilation, compared to TDC, when viewing social scenes versus geometric shapes. There was no statistically significant difference found between AS and ASD subjects in either social eye tracking or pupillometry. Conclusions and implications The use of eye tracking and pupillometry may represent an innovative measure for quantifying AS-associated impairments in social salience.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalResearch in Developmental Disabilities
Volume68
DOIs
StatePublished - Sep 1 2017

Fingerprint

Angelman Syndrome
Developmental Disabilities
Pupil
Nervous System Diseases
Caregivers
Dilatation
Seizures
Communication

Keywords

  • Angelman syndrome
  • Developmental disabilities
  • Eye tracking
  • Pupillometry

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology

Cite this

Hong, M. P., Guilfoyle, J. L., Mooney, L. N., Wink, L. K., Pedapati, E. V., Shaffer, R. C., ... Erickson, C. A. (2017). Eye gaze and pupillary response in Angelman syndrome. Research in Developmental Disabilities, 68, 88-94. https://doi.org/10.1016/j.ridd.2017.06.011

Eye gaze and pupillary response in Angelman syndrome. / Hong, Michael P.; Guilfoyle, Janna L.; Mooney, Lindsey N.; Wink, Logan K.; Pedapati, Ernest V.; Shaffer, Rebecca C.; Sweeney, John A.; Erickson, Craig A.

In: Research in Developmental Disabilities, Vol. 68, 01.09.2017, p. 88-94.

Research output: Contribution to journalArticle

Hong, MP, Guilfoyle, JL, Mooney, LN, Wink, LK, Pedapati, EV, Shaffer, RC, Sweeney, JA & Erickson, CA 2017, 'Eye gaze and pupillary response in Angelman syndrome', Research in Developmental Disabilities, vol. 68, pp. 88-94. https://doi.org/10.1016/j.ridd.2017.06.011
Hong MP, Guilfoyle JL, Mooney LN, Wink LK, Pedapati EV, Shaffer RC et al. Eye gaze and pupillary response in Angelman syndrome. Research in Developmental Disabilities. 2017 Sep 1;68:88-94. https://doi.org/10.1016/j.ridd.2017.06.011
Hong, Michael P. ; Guilfoyle, Janna L. ; Mooney, Lindsey N. ; Wink, Logan K. ; Pedapati, Ernest V. ; Shaffer, Rebecca C. ; Sweeney, John A. ; Erickson, Craig A. / Eye gaze and pupillary response in Angelman syndrome. In: Research in Developmental Disabilities. 2017 ; Vol. 68. pp. 88-94.
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