Eye Tracking and Mental Illness

D. L. Levy, J. A. Sweeney

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Eye-tracking abnormalities are one of the most promising endophenotypes for schizophrenia. Eye-tracking dysfunction (ETD) involves a primary disturbance in the smooth pursuit system and a secondary disturbance involving saccadic disinhibition. Eye tracking has high heritability. Linkage has been reported between ETD and loci on chromosome 6p. Recurrence risk for ETD in first-degree relatives of schizophrenics is much higher than that of schizophrenia, suggesting that ETD may be a more penetrant pleiotropic expression of gene(s) that increase the risk for schizophrenia and may therefore have greater power to identify schizophrenia-susceptibility genes than the clinical phenotype alone.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages179-184
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Affective disorders
  • Endophenotypes
  • Frontal eye fields
  • Medial superior temporal area
  • Middle temporal visual area
  • Motion processing
  • Pleiotropy
  • Posterior parietal cortex
  • Schizophrenia
  • Smooth pursuit eye movements

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Levy, D. L., & Sweeney, J. A. (2009). Eye Tracking and Mental Illness. In Encyclopedia of Neuroscience (pp. 179-184). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00399-5