Abstract
Eye-tracking abnormalities are one of the most promising endophenotypes for schizophrenia. Eye-tracking dysfunction (ETD) involves a primary disturbance in the smooth pursuit system and a secondary disturbance involving saccadic disinhibition. Eye tracking has high heritability. Linkage has been reported between ETD and loci on chromosome 6p. Recurrence risk for ETD in first-degree relatives of schizophrenics is much higher than that of schizophrenia, suggesting that ETD may be a more penetrant pleiotropic expression of gene(s) that increase the risk for schizophrenia and may therefore have greater power to identify schizophrenia-susceptibility genes than the clinical phenotype alone.
Original language | English (US) |
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Title of host publication | Encyclopedia of Neuroscience |
Publisher | Elsevier Ltd |
Pages | 179-184 |
Number of pages | 6 |
ISBN (Print) | 9780080450469 |
DOIs | |
State | Published - 2009 |
Keywords
- Affective disorders
- Endophenotypes
- Frontal eye fields
- Medial superior temporal area
- Middle temporal visual area
- Motion processing
- Pleiotropy
- Posterior parietal cortex
- Schizophrenia
- Smooth pursuit eye movements
ASJC Scopus subject areas
- General Neuroscience