Purpose: The current study characterized pleural changes induced by talc pleurodesis (TP), based on serial positron emission tomography/computer- tomography (PET/CT) with F-18 fluorodeoxyglucose (FDG). Materials and Methods: A total of 8 cancer patients who had both TP and PET/CT and no evidence of active pleural involvement after TP were retrospectively evaluatedMaximum standard uptake values, maximum Hounsfield units (HU), and thickness were followed over time. Results: The 8 patients had 25 PET/CT scans performed in an average of 22 months after TPAn increased FDG uptake was associated with an increase in pleural thickness within 5 months after TP, and both parameters showed statistical significance as compared with findings before TPAfter 5 months of TP, the standard uptake value appeared to persist or increase further, and the pleural thickening stabilizedThe formation of calcification was a slow process and might lag behind the changes in FDG metabolism and pleural thicknessThe HU did not change significantly once pleural calcification had been formed. Conclusions: Knowledge of aforementioned pleural changes may help differentiate TP induced pleural inflammation from pleural malignancy and to avoid false-positive interpretation of FDG PET/CT exams.
- F-18 FDG PET/CT
- Pleural changes
- Talc pleurodesis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging