Fabrication of 3d lymph node mimetic and its potential for cancer diagnosis

Amirhossein Hakamivala, Jer-Tsong Hsieh, Liping Tang.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Prostate cancer (PCa) is the third leading cause of cancer death in the United States [1]. A major cause for mortality is the recurrent metastatic castration-resistant PCa. In fact, lymph nodes (LNs) are often the first organs in which the initial metastases take place and metastatic LN (m-LN) has been used as a prognostic factor in cancer [2]. However, the processes governing LN cancer metastasis are not totally understood. Equally important, there is no in vitro model to mimic LN responses, which is the goal of this investigation. Our recent studies have uncovered that PCa metastasized LNs are able to release several chemokines to promote cancer migration. Based on this recent observation, the overall objective of this work was to develop a 3D LN mimetic device that can produce cancer chemokines in vitro similar to real metastasized LN.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - Jan 1 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Hakamivala, A., Hsieh, J-T., & Tang., L. (2019). Fabrication of 3d lymph node mimetic and its potential for cancer diagnosis. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.