Factor XIIIA Va134Leu polymorphism does not predict risk of coronary heart disease: The atherosclerosis risk in communities (ARIC) study

Nena Aleksic, Chul Ahn, Yao Wei Wang, Harinder Juneja, Aaron R. Folsom, Eric Boerwinkle, Kenneth K. Wu

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Factor XIII catalyzes the cross-linking of fibrin. Cross-sectional studies have suggested that a common polymorphism site at residue 34 of the A subunit of factor XIII (FXIIIA) with a substitution of Leu for Val (FXIIIA Va134Leu) was associated with reduced coronary heart disease (CHD). This association has not been examined in prospective studies. Healthy subjects (n=15 792) were recruited from 4 US communities into the Atherosclerosis Risk in Communities (ARIC) study from 1987 to 1989. They were followed, and incident CHD events were identified and verified. For the present study, we included 423 patients with CHD as cases and 479 noncases. FXIIIA Va134Leu polymorphism was determined by the single-strand conformational polymorphism method. There were no significant differences in the genotype frequencies between cases and noncases. The genotypes showed little association with known CHD risk factors. A weighted proportional hazards regression analysis adjusting for other risk factors confirmed no association of the genotypes with risk of CHD. This prospective study did not provide evidence of a reduced CHD risk for the FXIIIA 34Leu allele.

Original languageEnglish (US)
Pages (from-to)348-352
Number of pages5
JournalArteriosclerosis, thrombosis, and vascular biology
Volume22
Issue number2
DOIs
StatePublished - Jan 1 2002

Keywords

  • Coronary heart disease
  • Factor XIII
  • Factor XIIIA Va134Leu polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Factor XIIIA Va134Leu polymorphism does not predict risk of coronary heart disease: The atherosclerosis risk in communities (ARIC) study'. Together they form a unique fingerprint.

  • Cite this