Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study)

Christopher W. Puleo; Colby R Ayers; Sonia Garg; Ian J Neeland; Alana A. Lewis; Ambarish Pandey; Mark H. Drazner; James A. De Lemos

doi:10.2217/bmm-2021-0055

Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study)

Christopher W. Puleo, Colby R Ayers, Sonia Garg, Ian J Neeland, Alana A. Lewis, Ambarish Pandey, Mark H. Drazner, James A. De Lemos

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) associate with structural heart disease and heart failure risk in individuals without known cardiovascular disease (CVD). However, few data are available regarding whether factors influencing levels of these two biomarkers are similar or distinct. We performed serial measurement of NT-proBNP and hs-cTnT in a contemporary multiethnic cohort with extensive phenotyping, with the goal of identifying their respective biological determinants in a population without known or suspected CVD. Methods: We evaluated 1877 participants of the Dallas Heart Study who had NT-proBNP and hs-cTnT measured and were free from clinical CVD at the each of its two examinations (2000-2002 and 2007-2009). Variables collected included demographic and risk factors, high-sensitivity C-reactive protein, body composition via dual-energy x-ray absorptiometry, coronary artery calcium by computed tomography, and cardiac dimensions and function by cardiac MRI. Linear regression was used to identify associations of these factors with each biomarker at baseline and with changes in biomarkers over follow-up. Results: NT-proBNP and hs-cTnT were poorly correlated at baseline (Spearman rho 0.083, p = 0.015), with only moderate correlation between change values (rho 0.18, p < 0.001). hs-cTnT positively associated and NT-proBNP inversely associated with male gender and black race. At baseline, both NT-proBNP and hs-cTnT associated with left ventricular end-diastolic volume and wall thickness, but only NT-proBNP associated with left atrial size. Changes in cardiac dimensions between phases were more strongly associated with changes in NT-proBNP than hs-cTnT. NT-proBNP was more strongly associated with high-sensitivity C-reactive protein and measures of body composition than hs-cTnT. Conclusion: Among individuals without CVD in the general population, NT-proBNP and hs-cTnT are nonredundant biomarkers that are differentially associated with demographic and cardiac factors. These findings indicate that hs-cTnT and NT-proBNP may reflect different pathophysiological pathways.

Original language	English (US)
Pages (from-to)	1487-1498
Number of pages	12
Journal	Biomarkers in Medicine
Volume	15
Issue number	16
DOIs	https://doi.org/10.2217/bmm-2021-0055
State	Published - Nov 2021

Keywords

biostatistics
cardiology
heart failure

ASJC Scopus subject areas

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

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10.2217/bmm-2021-0055

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Puleo, C. W., Ayers, C. R., Garg, S., Neeland, I. J., Lewis, A. A., Pandey, A., Drazner, M. H., & De Lemos, J. A. (2021). Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study). Biomarkers in Medicine, 15(16), 1487-1498. https://doi.org/10.2217/bmm-2021-0055

@article{1318bcaf93ab4bbe8693982beb3b2abc,

title = "Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study)",

abstract = "Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) associate with structural heart disease and heart failure risk in individuals without known cardiovascular disease (CVD). However, few data are available regarding whether factors influencing levels of these two biomarkers are similar or distinct. We performed serial measurement of NT-proBNP and hs-cTnT in a contemporary multiethnic cohort with extensive phenotyping, with the goal of identifying their respective biological determinants in a population without known or suspected CVD. Methods: We evaluated 1877 participants of the Dallas Heart Study who had NT-proBNP and hs-cTnT measured and were free from clinical CVD at the each of its two examinations (2000-2002 and 2007-2009). Variables collected included demographic and risk factors, high-sensitivity C-reactive protein, body composition via dual-energy x-ray absorptiometry, coronary artery calcium by computed tomography, and cardiac dimensions and function by cardiac MRI. Linear regression was used to identify associations of these factors with each biomarker at baseline and with changes in biomarkers over follow-up. Results: NT-proBNP and hs-cTnT were poorly correlated at baseline (Spearman rho 0.083, p = 0.015), with only moderate correlation between change values (rho 0.18, p < 0.001). hs-cTnT positively associated and NT-proBNP inversely associated with male gender and black race. At baseline, both NT-proBNP and hs-cTnT associated with left ventricular end-diastolic volume and wall thickness, but only NT-proBNP associated with left atrial size. Changes in cardiac dimensions between phases were more strongly associated with changes in NT-proBNP than hs-cTnT. NT-proBNP was more strongly associated with high-sensitivity C-reactive protein and measures of body composition than hs-cTnT. Conclusion: Among individuals without CVD in the general population, NT-proBNP and hs-cTnT are nonredundant biomarkers that are differentially associated with demographic and cardiac factors. These findings indicate that hs-cTnT and NT-proBNP may reflect different pathophysiological pathways.",

keywords = "biostatistics, cardiology, heart failure",

author = "Puleo, {Christopher W.} and Ayers, {Colby R} and Sonia Garg and Neeland, {Ian J} and Lewis, {Alana A.} and Ambarish Pandey and Drazner, {Mark H.} and {De Lemos}, {James A.}",

note = "Funding Information: The DHS was supported by grants from the Donald W. Reynolds Foundation and the National Center for Advancing Translational Sciences (UL1TR001105). Biomarker measurements were supported by grants from Roche Diagnostics. JA de Lemos reports grant support from Roche Diagnostics and Abbott Diagnostics, consulting fees from Roche Diagnostics, Abbott Diagnostics, Ortho Clinical Diagnostics, Quidel Corporation and Siemen{\textquoteright}s Health Care Diagnostics. He has been named on a patent awarded to University of Maryland (US patent application number: 15/309,754) entitled: {\textquoteleft}Methods for Assessing Differential Risk for Developing Heart Failure{\textquoteright}. IJ Neeland reports that he is a former speaker and consultant for the Boehringer Ingelheim and Lilly Alliance. He is also a former scientific advisory board member of AMRA Medical. He has received grant support from the NIH, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and Novo Nordisk. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2021 Future Medicine Ltd.",

year = "2021",

month = nov,

doi = "10.2217/bmm-2021-0055",

language = "English (US)",

volume = "15",

pages = "1487--1498",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

number = "16",

}

TY - JOUR

T1 - Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study)

AU - Puleo, Christopher W.

AU - Ayers, Colby R

AU - Garg, Sonia

AU - Neeland, Ian J

AU - Lewis, Alana A.

AU - Pandey, Ambarish

AU - Drazner, Mark H.

AU - De Lemos, James A.

N1 - Funding Information: The DHS was supported by grants from the Donald W. Reynolds Foundation and the National Center for Advancing Translational Sciences (UL1TR001105). Biomarker measurements were supported by grants from Roche Diagnostics. JA de Lemos reports grant support from Roche Diagnostics and Abbott Diagnostics, consulting fees from Roche Diagnostics, Abbott Diagnostics, Ortho Clinical Diagnostics, Quidel Corporation and Siemen’s Health Care Diagnostics. He has been named on a patent awarded to University of Maryland (US patent application number: 15/309,754) entitled: ‘Methods for Assessing Differential Risk for Developing Heart Failure’. IJ Neeland reports that he is a former speaker and consultant for the Boehringer Ingelheim and Lilly Alliance. He is also a former scientific advisory board member of AMRA Medical. He has received grant support from the NIH, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and Novo Nordisk. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2021 Future Medicine Ltd.

PY - 2021/11

Y1 - 2021/11

N2 - Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) associate with structural heart disease and heart failure risk in individuals without known cardiovascular disease (CVD). However, few data are available regarding whether factors influencing levels of these two biomarkers are similar or distinct. We performed serial measurement of NT-proBNP and hs-cTnT in a contemporary multiethnic cohort with extensive phenotyping, with the goal of identifying their respective biological determinants in a population without known or suspected CVD. Methods: We evaluated 1877 participants of the Dallas Heart Study who had NT-proBNP and hs-cTnT measured and were free from clinical CVD at the each of its two examinations (2000-2002 and 2007-2009). Variables collected included demographic and risk factors, high-sensitivity C-reactive protein, body composition via dual-energy x-ray absorptiometry, coronary artery calcium by computed tomography, and cardiac dimensions and function by cardiac MRI. Linear regression was used to identify associations of these factors with each biomarker at baseline and with changes in biomarkers over follow-up. Results: NT-proBNP and hs-cTnT were poorly correlated at baseline (Spearman rho 0.083, p = 0.015), with only moderate correlation between change values (rho 0.18, p < 0.001). hs-cTnT positively associated and NT-proBNP inversely associated with male gender and black race. At baseline, both NT-proBNP and hs-cTnT associated with left ventricular end-diastolic volume and wall thickness, but only NT-proBNP associated with left atrial size. Changes in cardiac dimensions between phases were more strongly associated with changes in NT-proBNP than hs-cTnT. NT-proBNP was more strongly associated with high-sensitivity C-reactive protein and measures of body composition than hs-cTnT. Conclusion: Among individuals without CVD in the general population, NT-proBNP and hs-cTnT are nonredundant biomarkers that are differentially associated with demographic and cardiac factors. These findings indicate that hs-cTnT and NT-proBNP may reflect different pathophysiological pathways.

AB - Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) associate with structural heart disease and heart failure risk in individuals without known cardiovascular disease (CVD). However, few data are available regarding whether factors influencing levels of these two biomarkers are similar or distinct. We performed serial measurement of NT-proBNP and hs-cTnT in a contemporary multiethnic cohort with extensive phenotyping, with the goal of identifying their respective biological determinants in a population without known or suspected CVD. Methods: We evaluated 1877 participants of the Dallas Heart Study who had NT-proBNP and hs-cTnT measured and were free from clinical CVD at the each of its two examinations (2000-2002 and 2007-2009). Variables collected included demographic and risk factors, high-sensitivity C-reactive protein, body composition via dual-energy x-ray absorptiometry, coronary artery calcium by computed tomography, and cardiac dimensions and function by cardiac MRI. Linear regression was used to identify associations of these factors with each biomarker at baseline and with changes in biomarkers over follow-up. Results: NT-proBNP and hs-cTnT were poorly correlated at baseline (Spearman rho 0.083, p = 0.015), with only moderate correlation between change values (rho 0.18, p < 0.001). hs-cTnT positively associated and NT-proBNP inversely associated with male gender and black race. At baseline, both NT-proBNP and hs-cTnT associated with left ventricular end-diastolic volume and wall thickness, but only NT-proBNP associated with left atrial size. Changes in cardiac dimensions between phases were more strongly associated with changes in NT-proBNP than hs-cTnT. NT-proBNP was more strongly associated with high-sensitivity C-reactive protein and measures of body composition than hs-cTnT. Conclusion: Among individuals without CVD in the general population, NT-proBNP and hs-cTnT are nonredundant biomarkers that are differentially associated with demographic and cardiac factors. These findings indicate that hs-cTnT and NT-proBNP may reflect different pathophysiological pathways.

KW - biostatistics

KW - cardiology

KW - heart failure

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U2 - 10.2217/bmm-2021-0055

DO - 10.2217/bmm-2021-0055

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AN - SCOPUS:85119189638

SN - 1752-0363

VL - 15

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EP - 1498

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 16

ER -

Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study)

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