Factors associated with increased survival after surgical resection of glioblastoma in octogenarians

Kalil G. Abdullah, Ashwin Ramayya, Jayesh P. Thawani, Lukasz Macyszyn, Maria Martinez-Lage, Donald M. O'Rourke, Steven Brem

Research output: Contribution to journalArticle

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Abstract

Elderly patients with glioblastoma represent a clinical challenge for neurosurgeons and oncologists. The data available on outcomes of patients greater than 80 undergoing resection is limited. In this study, factors linked to increased survival in patients over the age of 80 were analyzed. A retrospective chart review of all patients over the age of 80 with a new diagnosis of glioblastoma and who underwent surgical resection with intent for maximal resection were examined. Patients who had only stereotactic biopsies were excluded. Immunohistochemical expression of oncogenic drivers (p53, EGFR, IDH-1) and a marker of cell proliferation (Ki-67 index) performed upon routine neuropathological examination were recorded. Stepwise logistic regression and Kaplan Meier survival curves were plotted to determine correlations to overall survival. Fifty-eight patients fit inclusion criteria with a mean age of 83 (range 80-93 years). The overall median survival was 4.2 months. There was a statistically significant correlation between Karnofsky Performance Status (KPS) and overall survival (P < 0.05). There was a significantly longer survival among patients undergoing either radiation alone or radiation and chemotherapy compared to those who underwent no postoperative adjuvant therapy (p < 0.05). There was also an association between overall survival and lack of p53 expression (p < 0.001) and lack of EGFR expression (p <0.05). In this very elderly population, overall survival advantage was conferred to those with higher preoperative KPS, postoperative adjuvant therapy, and lack of protein expression of EGFR and p53. These findings may be useful in clinical decision analysis for management of patients with glioblastoma who are octogenarians, and also validate the critical role of EGFR and p53 expression in oncogenesis, particularly with advancing age.

Original languageEnglish (US)
Article number0127202
JournalPloS one
Volume10
Issue number5
DOIs
StatePublished - May 15 2015
Externally publishedYes

Fingerprint

resection
Glioblastoma
Radiation
Chemotherapy
Survival
Biopsy
Decision theory
Cell proliferation
Logistics
Karnofsky Performance Status
adjuvants
Proteins
therapeutics
Decision Support Techniques
Kaplan-Meier Estimate
carcinogenesis
drug therapy
biopsy
cell proliferation
Carcinogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Abdullah, K. G., Ramayya, A., Thawani, J. P., Macyszyn, L., Martinez-Lage, M., O'Rourke, D. M., & Brem, S. (2015). Factors associated with increased survival after surgical resection of glioblastoma in octogenarians. PloS one, 10(5), [0127202]. https://doi.org/10.1371/journal.pone.0127202

Factors associated with increased survival after surgical resection of glioblastoma in octogenarians. / Abdullah, Kalil G.; Ramayya, Ashwin; Thawani, Jayesh P.; Macyszyn, Lukasz; Martinez-Lage, Maria; O'Rourke, Donald M.; Brem, Steven.

In: PloS one, Vol. 10, No. 5, 0127202, 15.05.2015.

Research output: Contribution to journalArticle

Abdullah, KG, Ramayya, A, Thawani, JP, Macyszyn, L, Martinez-Lage, M, O'Rourke, DM & Brem, S 2015, 'Factors associated with increased survival after surgical resection of glioblastoma in octogenarians', PloS one, vol. 10, no. 5, 0127202. https://doi.org/10.1371/journal.pone.0127202
Abdullah, Kalil G. ; Ramayya, Ashwin ; Thawani, Jayesh P. ; Macyszyn, Lukasz ; Martinez-Lage, Maria ; O'Rourke, Donald M. ; Brem, Steven. / Factors associated with increased survival after surgical resection of glioblastoma in octogenarians. In: PloS one. 2015 ; Vol. 10, No. 5.
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