Factors associated with post-ERCP pancreatitis and the effect of pancreatic duct stenting in a pediatric population

David M. Troendle, Omana Abraham, Rong Huang, Bradley A. Barth

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background Risk factors for the development of post-ERCP pancreatitis (PEP) have not been identified in the pediatric population. It remains unclear what constitutes appropriate prophylaxis in this patient population. Objectives To assess the prevalence and severity of PEP in the pediatric population and identify factors associated with developing PEP and to evaluate the effect of prophylactic pancreatic duct stenting in high-risk patients. Design Retrospective analysis of an ERCP database at a single large pediatric center. Setting Academic center. Patients A total of 432 ERCPs performed on 313 patients younger than 19 years of age from January 2004 to October 2013. Intervention ERCP for any indication. Main Outcome Measurements Rates and severity of PEP, preprocedural and procedural risk factors for the development of PEP, and the effect of pancreatic stents on preventing PEP in high-risk patients. Results PEP occurred after 47 procedures (prevalence, 10.9%). Thirty-four cases were mild, 9 were moderate, and 4 were severe. There was no mortality. On multiple logistic analysis, pancreatic duct injection (P <.0001; odds ratio 30.8; 95% confidence interval [CI], 9.1-103.9) and pancreatic sphincterotomy (P <.01; OR 3.8; 95% CI, 1.6-9.8) were positively associated with PEP. A history of chronic pancreatitis was negatively associated with PEP (P <.05; OR 0.37; 95% CI, 0.15-0.93). On subset analysis, placing a prophylactic pancreatic stent was associated with significantly increased rates of PEP in patients with pancreatic duct injection compared with those who had no attempt at stent placement (P <.01). Two patients with severe pancreatitis had prophylactic pancreatic stents in place. Limitations Retrospective investigation. Conclusions In the pediatric population, pancreatic duct injection and pancreatic sphincterotomy are associated with significantly increased rates of PEP, whereas a history of chronic pancreatitis is negatively associated. Prophylactic pancreatic stenting is associated with higher rates of PEP in high-risk patients and does not eliminate severe PEP.

Original languageEnglish (US)
Pages (from-to)1408-1416
Number of pages9
JournalGastrointestinal Endoscopy
Volume81
Issue number6
DOIs
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Factors associated with post-ERCP pancreatitis and the effect of pancreatic duct stenting in a pediatric population'. Together they form a unique fingerprint.

Cite this