Factors associated with retention among non-perinatally HIV-infected youth in the HIV research network

HIV Research Network

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally HIV (nPHIV)-infected youth associated with retention 1 year after initiating care and in the 2 years thereafter. We also assessed the impact retention in year 1 had on retention in years 2 and 3. Methods: This was a retrospective analysis of treatment-naive nPHIV-infected 12-to 24-year-old youth presenting for care in 16 US HIV clinical sites within the HIV Research Network between 2002 and 2008. Multivariate logistic regression identified factors associated with retention. Results: Of 1160 nPHIV-infected youth, 44.6% were retained in care during the first year, and 22.4% were retained in all 3 years. Retention in the first year was associated with starting antiretroviral therapy in the first year (adjusted odds ratio [AOR], 3.47 [95% confidence interval (CI), 2.57-4.67]), Hispanic ethnicity (AOR, 1.66 [95% CI, 1.08-2.56]), men who have sex with men (AOR, 1.59 [95% CI, 1.07-2.36]), and receiving care at a pediatric site (AOR, 5.37 [95% CI, 3.20-9.01]). Retention in years 2 and 3 was associated with being retained 1 year after initiating care (AOR, 7.44 [95% CI, 5.11-10.83]). Conclusion: A high proportion of newly enrolled nPHIV-infected youth were not retained for 1 year, and only 1 in 4 were retained for 3 years. Patients who were Hispanic, were men who have sex with men, or were seen at pediatric clinics were more likely to be retained in care. Interventions that target those at risk of being lost to follow up are essential for this high-risk population.

Original languageEnglish (US)
Article numberpiu102
Pages (from-to)39-46
Number of pages8
JournalJournal of the Pediatric Infectious Diseases Society
Volume5
Issue number1
DOIs
StatePublished - Oct 31 2015

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HIV
Research
Odds Ratio
Confidence Intervals
Risk-Taking
Hispanic Americans
Pediatrics
Lost to Follow-Up
Logistic Models
Demography
Therapeutics
Population

Keywords

  • Adolescents
  • HIV Research Network
  • Retention
  • Youth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Factors associated with retention among non-perinatally HIV-infected youth in the HIV research network. / HIV Research Network.

In: Journal of the Pediatric Infectious Diseases Society, Vol. 5, No. 1, piu102, 31.10.2015, p. 39-46.

Research output: Contribution to journalArticle

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title = "Factors associated with retention among non-perinatally HIV-infected youth in the HIV research network",
abstract = "Background: The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally HIV (nPHIV)-infected youth associated with retention 1 year after initiating care and in the 2 years thereafter. We also assessed the impact retention in year 1 had on retention in years 2 and 3. Methods: This was a retrospective analysis of treatment-naive nPHIV-infected 12-to 24-year-old youth presenting for care in 16 US HIV clinical sites within the HIV Research Network between 2002 and 2008. Multivariate logistic regression identified factors associated with retention. Results: Of 1160 nPHIV-infected youth, 44.6{\%} were retained in care during the first year, and 22.4{\%} were retained in all 3 years. Retention in the first year was associated with starting antiretroviral therapy in the first year (adjusted odds ratio [AOR], 3.47 [95{\%} confidence interval (CI), 2.57-4.67]), Hispanic ethnicity (AOR, 1.66 [95{\%} CI, 1.08-2.56]), men who have sex with men (AOR, 1.59 [95{\%} CI, 1.07-2.36]), and receiving care at a pediatric site (AOR, 5.37 [95{\%} CI, 3.20-9.01]). Retention in years 2 and 3 was associated with being retained 1 year after initiating care (AOR, 7.44 [95{\%} CI, 5.11-10.83]). Conclusion: A high proportion of newly enrolled nPHIV-infected youth were not retained for 1 year, and only 1 in 4 were retained for 3 years. Patients who were Hispanic, were men who have sex with men, or were seen at pediatric clinics were more likely to be retained in care. Interventions that target those at risk of being lost to follow up are essential for this high-risk population.",
keywords = "Adolescents, HIV Research Network, Retention, Youth",
author = "{HIV Research Network} and Charles Farmer and Yehia, {Baligh R.} and Fleishman, {John A.} and Richard Rutstein and Mathews, {W. Christopher} and Ank Nijhawan and Moore, {Richard D.} and Gebo, {Kelly A.} and Agwu, {Allison L.}",
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T1 - Factors associated with retention among non-perinatally HIV-infected youth in the HIV research network

AU - HIV Research Network

AU - Farmer, Charles

AU - Yehia, Baligh R.

AU - Fleishman, John A.

AU - Rutstein, Richard

AU - Mathews, W. Christopher

AU - Nijhawan, Ank

AU - Moore, Richard D.

AU - Gebo, Kelly A.

AU - Agwu, Allison L.

PY - 2015/10/31

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N2 - Background: The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally HIV (nPHIV)-infected youth associated with retention 1 year after initiating care and in the 2 years thereafter. We also assessed the impact retention in year 1 had on retention in years 2 and 3. Methods: This was a retrospective analysis of treatment-naive nPHIV-infected 12-to 24-year-old youth presenting for care in 16 US HIV clinical sites within the HIV Research Network between 2002 and 2008. Multivariate logistic regression identified factors associated with retention. Results: Of 1160 nPHIV-infected youth, 44.6% were retained in care during the first year, and 22.4% were retained in all 3 years. Retention in the first year was associated with starting antiretroviral therapy in the first year (adjusted odds ratio [AOR], 3.47 [95% confidence interval (CI), 2.57-4.67]), Hispanic ethnicity (AOR, 1.66 [95% CI, 1.08-2.56]), men who have sex with men (AOR, 1.59 [95% CI, 1.07-2.36]), and receiving care at a pediatric site (AOR, 5.37 [95% CI, 3.20-9.01]). Retention in years 2 and 3 was associated with being retained 1 year after initiating care (AOR, 7.44 [95% CI, 5.11-10.83]). Conclusion: A high proportion of newly enrolled nPHIV-infected youth were not retained for 1 year, and only 1 in 4 were retained for 3 years. Patients who were Hispanic, were men who have sex with men, or were seen at pediatric clinics were more likely to be retained in care. Interventions that target those at risk of being lost to follow up are essential for this high-risk population.

AB - Background: The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally HIV (nPHIV)-infected youth associated with retention 1 year after initiating care and in the 2 years thereafter. We also assessed the impact retention in year 1 had on retention in years 2 and 3. Methods: This was a retrospective analysis of treatment-naive nPHIV-infected 12-to 24-year-old youth presenting for care in 16 US HIV clinical sites within the HIV Research Network between 2002 and 2008. Multivariate logistic regression identified factors associated with retention. Results: Of 1160 nPHIV-infected youth, 44.6% were retained in care during the first year, and 22.4% were retained in all 3 years. Retention in the first year was associated with starting antiretroviral therapy in the first year (adjusted odds ratio [AOR], 3.47 [95% confidence interval (CI), 2.57-4.67]), Hispanic ethnicity (AOR, 1.66 [95% CI, 1.08-2.56]), men who have sex with men (AOR, 1.59 [95% CI, 1.07-2.36]), and receiving care at a pediatric site (AOR, 5.37 [95% CI, 3.20-9.01]). Retention in years 2 and 3 was associated with being retained 1 year after initiating care (AOR, 7.44 [95% CI, 5.11-10.83]). Conclusion: A high proportion of newly enrolled nPHIV-infected youth were not retained for 1 year, and only 1 in 4 were retained for 3 years. Patients who were Hispanic, were men who have sex with men, or were seen at pediatric clinics were more likely to be retained in care. Interventions that target those at risk of being lost to follow up are essential for this high-risk population.

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